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Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.date.accessioned | 2020-07-02T17:34:43Z | - |
dc.date.available | 2020-07-02T17:34:43Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176906 | - |
dc.description.abstract | Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, but the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 mumol) onto the shaven backs of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[alpha]anthracene did not cause any significant increase in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control. Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis when given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. | - |
dc.description.statementOfResponsibility | prohibition | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | 9,10-Dimethyl-1,2-benzanthracene/toxicity | - |
dc.subject.MESH | Acetone/toxicity | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Capsaicin/toxicity* | - |
dc.subject.MESH | Capsicum/toxicity* | - |
dc.subject.MESH | Carcinogens/toxicity* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hyperplasia | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Papilloma/chemically induced* | - |
dc.subject.MESH | Papilloma/pathology | - |
dc.subject.MESH | Plants, Medicinal* | - |
dc.subject.MESH | Skin/drug effects | - |
dc.subject.MESH | Skin/pathology* | - |
dc.subject.MESH | Skin Neoplasms/chemically induced* | - |
dc.subject.MESH | Skin Neoplasms/pathology | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/toxicity | - |
dc.subject.MESH | Time Factors | - |
dc.title | Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Kwanghyoun Park | - |
dc.contributor.googleauthor | Kwan Sik Chun | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Young Joon Surh | - |
dc.contributor.localId | A01429 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 9891468 | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | 박광균 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6A | - |
dc.citation.startPage | 4201 | - |
dc.citation.endPage | 4205 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.18(6A) : 4201-4205, 1998 | - |
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