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Mechanical and electrophysiological effects of mepivacaine on direct myocardial depression in vitro

Authors
 W. KON PARK  ;  C. KOOK SUH 
Citation
 BRITISH JOURNAL OF ANAESTHESIA, Vol.81(2) : 244-246, 1998 
Journal Title
 BRITISH JOURNAL OF ANAESTHESIA 
ISSN
 0007-0912 
Issue Date
1998
MeSH
Anesthetics, Local/pharmacology* ; Animals ; Culture Media ; Culture Techniques ; Depression, Chemical ; Dose-Response Relationship, Drug ; Electrophysiology ; Female ; Guinea Pigs ; Hypothermia, Induced ; Isotonic Solutions ; Mepivacaine/pharmacology* ; Myocardial Contraction/drug effects* ; Papillary Muscles/drug effects ; Rats ; Rats, Sprague-Dawley
Abstract
The effects of various concentrations (20, 50, and 100 mumol litre-1) of mepivacaine were studied in isolated guinea pig and rat right ventricular papillary muscles by measuring the effects on myocardial contractility and electrophysiological parameters. Mepivacaine produced dose-dependent depression of peak force during 0.5 to 3 Hz stimulation rates in guinea pig papillary muscles. Conduction block was frequently noted, especially at higher stimulation rates (2 and 3 Hz) with mepivacaine 50 and 100 mumol litre-1. In rat papillary muscle experiments, about 20% depression of peak force was shown at rested state contraction. Shortening of action potential (AP) duration (APD50: about 10%, APD90: about 10%) and rate-dependent depression of dV/dt max was observed with mepivacaine 100 mumol litre-1. In 26 mmol litre-1 K+ Tyrode's solution, mepivacaine 50 and 100 mumol litre-1 produced a dose-dependent depression of early (50 mumol litre-1: about 20%, 100 mumol litre-1: about 30%) and late (50 mumol litre-1: about 30%, 100 mumol litre-1: about 50%) force development. In slow APs, neither shortening of AP duration nor changes of dV/dt max were shown by mepivacaine 100 mumol litre-1. An approximate 30% depression of contracture induced by rapid cooling after 2 Hz stimulation rates was observed with mepivacaine 100 mumol litre-1. It may be concluded that the direct myocardial depressant effect of mepivacaine is likely to be caused by inhibition of Ca2+ release from the sarcoplasmic reticulum. The Na+ channel blocking action may contribute indirectly to the depression of contractility.
Files in This Item:
T199802636.pdf Download
DOI
10.1093/bja/81.2.244
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Park, Wyun Kon(박윤곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176892
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