Cited 3 times in
Mechanical and electrophysiological effects of mepivacaine on direct myocardial depression in vitro
DC Field | Value | Language |
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dc.contributor.author | 박윤곤 | - |
dc.date.accessioned | 2020-07-02T17:33:36Z | - |
dc.date.available | 2020-07-02T17:33:36Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176892 | - |
dc.description.abstract | The effects of various concentrations (20, 50, and 100 mumol litre-1) of mepivacaine were studied in isolated guinea pig and rat right ventricular papillary muscles by measuring the effects on myocardial contractility and electrophysiological parameters. Mepivacaine produced dose-dependent depression of peak force during 0.5 to 3 Hz stimulation rates in guinea pig papillary muscles. Conduction block was frequently noted, especially at higher stimulation rates (2 and 3 Hz) with mepivacaine 50 and 100 mumol litre-1. In rat papillary muscle experiments, about 20% depression of peak force was shown at rested state contraction. Shortening of action potential (AP) duration (APD50: about 10%, APD90: about 10%) and rate-dependent depression of dV/dt max was observed with mepivacaine 100 mumol litre-1. In 26 mmol litre-1 K+ Tyrode's solution, mepivacaine 50 and 100 mumol litre-1 produced a dose-dependent depression of early (50 mumol litre-1: about 20%, 100 mumol litre-1: about 30%) and late (50 mumol litre-1: about 30%, 100 mumol litre-1: about 50%) force development. In slow APs, neither shortening of AP duration nor changes of dV/dt max were shown by mepivacaine 100 mumol litre-1. An approximate 30% depression of contracture induced by rapid cooling after 2 Hz stimulation rates was observed with mepivacaine 100 mumol litre-1. It may be concluded that the direct myocardial depressant effect of mepivacaine is likely to be caused by inhibition of Ca2+ release from the sarcoplasmic reticulum. The Na+ channel blocking action may contribute indirectly to the depression of contractility. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anesthetics, Local/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Culture Media | - |
dc.subject.MESH | Culture Techniques | - |
dc.subject.MESH | Depression, Chemical | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Electrophysiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | Hypothermia, Induced | - |
dc.subject.MESH | Isotonic Solutions | - |
dc.subject.MESH | Mepivacaine/pharmacology* | - |
dc.subject.MESH | Myocardial Contraction/drug effects* | - |
dc.subject.MESH | Papillary Muscles/drug effects | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Mechanical and electrophysiological effects of mepivacaine on direct myocardial depression in vitro | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | W. KON PARK | - |
dc.contributor.googleauthor | C. KOOK SUH | - |
dc.identifier.doi | 10.1093/bja/81.2.244 | - |
dc.contributor.localId | A01593 | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 9813531 | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | 박윤곤 | - |
dc.citation.volume | 81 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 244 | - |
dc.citation.endPage | 246 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.81(2) : 244-246, 1998 | - |
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