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태아 흉선세포와 간 림프구에서 NK cell receptor 의 발현과 SSCP를 이용한 다양성 분석.

Other Titles
 Expression of p58 in Fetal Thymocytes and Fetal Liver Lymphocytes 
 Dae-Ho Kwon  ;  Eui-Cheol Shin  ;  Hyung-Woo Park  ;  Jeon-Soo Shin  ;  Se-Jong Kim  ;  Joo-Deuk Kim  ;  In-Hong Choi 
 Korean Journal of Immunology (대한면역학회지), Vol.20(1) : 17-23, 1998 
Journal Title
 Korean Journal of Immunology (대한면역학회지) 
Issue Date
Bipotent progenitors for T and natural killer (NK) lymphocytes are thought to exist among early precursor thymocytes or liver lymphocytes. The identification of such a progenitor population or mature NK cells in such organs remains undefined. Here we report the identification of a novel receptor of NK cells, p58 (HLA class 1-specific inhibitory receptors), in fetal thymocytes and fetal-liver iymphocytes. Our finding suggests the NK cells mature in the developmental stage during fetal ontogeny. Flow cytometric analysis revealed p58 positive cells in thymocytes or in fetal liver lymphocytes and reverse transcription PCR also showed amplification of p58 RNA. The result of single stranded conformational polymorphism (SSCP) showed it discriminates one or two base pairdifferences of the p58 gene. Although the question still remains as to whether the expression of p58 is due to the NK cells or natural T cells, it is clear the p58 is expressed in fetal thymocytes or liver lymphocytes. And SSCP analysisusing appropriate sets of primers used in this study, is helpful to study the diversity of p58.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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