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Expression of p58 in fetal thymocytes and fetal liver lymphocytes.

 Joo Deuk Kim  ;  In Hong Choi  ;  Jeon Soo Shin  ;  Se Jong Kim  ;  Dae Ho Kwon  ;  Hyung Woo Park  ;  Eui Cheol Shin 
 Korean Journal of Immunology (대한면역학회지), Vol.20(1) : 17-24, 1998 
Journal Title
 Korean Journal of Immunology (대한면역학회지) 
Issue Date
Fetal thymocytes ; Fetal liver lymphocytes ; NK cell receptor ; 'p58
Bipotent progenitors for T and natural killer (NK) lymphocytes are thought to exist among early precursor thymocytes or liver lymphocytes. The identification of such a progenitor population or mature NK cells in such organs remains undefined. Here we report the identification of a novel receptor of NK cells, p58 (HLA class I-specific inhibitory receptors), in fetal thymocytes and fetal liver lymphocytes. Our finding suggests the NK cells mature in the developmental stage during feta1 ontogeny. Flow cytometric analysis revealed p58 positive cells in thymocytes or in fetal liver lymphocytes and reverse transcription PCR also showed amplification of p58 RNA. The result of single stranded conformational polymorphism (SSCP) showed it discriminates one or two base pair differences of the p58 gene. Although the question still remains as to whether the expression of p58 is due to the NK cells or natural T cells, it is clear the p58 is expressed in fetal thymocytes or liver lymphocytes. And SSCP analysis using appropriate sets of primers used in this study, is helpful to study the diversity of p58.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Park, Hyoung Woo(박형우) ORCID logo https://orcid.org/0000-0002-5341-9249
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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