7 13

Cited 0 times in

증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구

Other Titles
 Collagen Synthesis by RPE Cells Associated with Proliferative Vitreoretinopathy 
 이성철  ;  권오웅  ;  김순현 
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.39(8) : 1801-1807, 1998 
Journal Title
 Journal of the Korean Ophthalmological Society (대한안과학회지) 
Issue Date
Collagen, which is newly synthesized by the cellular component, is the major component of extracellular matrix in PVR membranes. The effects of transforming growth factor(TGF)-β in the synthesis of collagen were evaluated. Tissue culture of PVR membrane was incubated for 19 hours with or without TGF-β in the absence of serum. Newly synthesized collagen in the membrane were measured by a collagenase-digestion assay. The biosynthetically labeled collagens were analyzed on SDS-polyacrylamide gel electro-phoresis. Collagen synthesis was dose-dependently stimulated by TGFβ. At a concentration of 1ng/㎖ of TGFβ1or TGFβ2,at a concentration of 10ng/㎖, induced a 90-125% increase in collagen synthesis over that of controls. PVR membranes in culture synthesized predominantly type I, III and V collagen. In conclusion TGFβ are potent stimulants of collagen.
Files in This Item:
T199802077.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.