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증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구

Other Titles
 Collagen Synthesis by RPE Cells Associated with Proliferative Vitreoretinopathy 
Authors
 이성철  ;  권오웅  ;  김순현 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.39(8) : 1801-1807, 1998 
Journal Title
 Journal of the Korean Ophthalmological Society (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
1998
Abstract
Collagen, which is newly synthesized by the cellular component, is the major component of extracellular matrix in PVR membranes. The effects of transforming growth factor(TGF)-β in the synthesis of collagen were evaluated. Tissue culture of PVR membrane was incubated for 19 hours with or without TGF-β in the absence of serum. Newly synthesized collagen in the membrane were measured by a collagenase-digestion assay. The biosynthetically labeled collagens were analyzed on SDS-polyacrylamide gel electro-phoresis. Collagen synthesis was dose-dependently stimulated by TGFβ. At a concentration of 1ng/㎖ of TGFβ1or TGFβ2,at a concentration of 10ng/㎖, induced a 90-125% increase in collagen synthesis over that of controls. PVR membranes in culture synthesized predominantly type I, III and V collagen. In conclusion TGFβ are potent stimulants of collagen.
Files in This Item:
T199802077.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176703
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