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증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구

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dc.contributor.author권오웅-
dc.date.accessioned2020-07-02T17:15:59Z-
dc.date.available2020-07-02T17:15:59Z-
dc.date.issued1998-
dc.identifier.issn0378-6471-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176703-
dc.description.abstractCollagen, which is newly synthesized by the cellular component, is the major component of extracellular matrix in PVR membranes. The effects of transforming growth factor(TGF)-β in the synthesis of collagen were evaluated. Tissue culture of PVR membrane was incubated for 19 hours with or without TGF-β in the absence of serum. Newly synthesized collagen in the membrane were measured by a collagenase-digestion assay. The biosynthetically labeled collagens were analyzed on SDS-polyacrylamide gel electro-phoresis. Collagen synthesis was dose-dependently stimulated by TGFβ. At a concentration of 1ng/㎖ of TGFβ1or TGFβ2,at a concentration of 10ng/㎖, induced a 90-125% increase in collagen synthesis over that of controls. PVR membranes in culture synthesized predominantly type I, III and V collagen. In conclusion TGFβ are potent stimulants of collagen.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한안과학회-
dc.relation.isPartOfJournal of the Korean Ophthalmological Society (대한안과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구-
dc.title.alternativeCollagen Synthesis by RPE Cells Associated with Proliferative Vitreoretinopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthor이성철-
dc.contributor.googleauthor권오웅-
dc.contributor.googleauthor김순현-
dc.contributor.localIdA00235-
dc.relation.journalcodeJ01838-
dc.identifier.eissn2092-9374-
dc.contributor.alternativeNameKwon, Oh Woong-
dc.contributor.affiliatedAuthor권오웅-
dc.citation.volume39-
dc.citation.number8-
dc.citation.startPage1801-
dc.citation.endPage1807-
dc.identifier.bibliographicCitationJournal of the Korean Ophthalmological Society (대한안과학회지), Vol.39(8) : 1801-1807, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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