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증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 권오웅 | - |
dc.date.accessioned | 2020-07-02T17:15:59Z | - |
dc.date.available | 2020-07-02T17:15:59Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0378-6471 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176703 | - |
dc.description.abstract | Collagen, which is newly synthesized by the cellular component, is the major component of extracellular matrix in PVR membranes. The effects of transforming growth factor(TGF)-β in the synthesis of collagen were evaluated. Tissue culture of PVR membrane was incubated for 19 hours with or without TGF-β in the absence of serum. Newly synthesized collagen in the membrane were measured by a collagenase-digestion assay. The biosynthetically labeled collagens were analyzed on SDS-polyacrylamide gel electro-phoresis. Collagen synthesis was dose-dependently stimulated by TGFβ. At a concentration of 1ng/㎖ of TGFβ1or TGFβ2,at a concentration of 10ng/㎖, induced a 90-125% increase in collagen synthesis over that of controls. PVR membranes in culture synthesized predominantly type I, III and V collagen. In conclusion TGFβ are potent stimulants of collagen. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한안과학회 | - |
dc.relation.isPartOf | Journal of the Korean Ophthalmological Society (대한안과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 증식초자체망막병증에서 망막색소상피세포의 콜라젠합성에 관한 연구 | - |
dc.title.alternative | Collagen Synthesis by RPE Cells Associated with Proliferative Vitreoretinopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | 이성철 | - |
dc.contributor.googleauthor | 권오웅 | - |
dc.contributor.googleauthor | 김순현 | - |
dc.contributor.localId | A00235 | - |
dc.relation.journalcode | J01838 | - |
dc.identifier.eissn | 2092-9374 | - |
dc.contributor.alternativeName | Kwon, Oh Woong | - |
dc.contributor.affiliatedAuthor | 권오웅 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1801 | - |
dc.citation.endPage | 1807 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.39(8) : 1801-1807, 1998 | - |
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