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TGF-β2 및 bFGF 망막색소상피세포 증식에 미치는 영향

Other Titles
 The Effects of TGF-β2 and bFGF on the Proliferation of Retinal Pigment Epithelial Cells 
Authors
 윤희성  ;  노세현  ;  이성철  ;  정진희  ;  유영현 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.36(9) : 1192-1203, 1998 
Journal Title
 Journal of the Korean Ophthalmological Society (대한안과학회지) 
ISSN
 0378-6471 
Issue Date
1998
Abstract
This study was undertaken to document the effect of transforming growth factor-β2 ( TGF-β2(TGF-β2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas bFGF increased the proliferation, TGF-β2 showed the inhibitory effect on the proliferation The inhibitory effect of TGF-β2 disappeared in RPE subcultured with 10ng/ml of bFGF. Both TGF-β2- and bFGF-specific antisense oligonucleotides blocked the autocrine effect of the growth factors. PLC-71 -specific antisense oligonucleotide inhibited the effect of TGF-β2 and bFGF. Genistein inhibited the effect of TGF-β2 and bFGF in dose-dependent man, ner. The data suggest the involvement. of in PLC-/1 and tyrosine kinase in signalling
Files in This Item:
T199801869.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176620
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