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TGF-β2 및 bFGF 망막색소상피세포 증식에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오웅 | - |
dc.date.accessioned | 2020-07-02T17:08:44Z | - |
dc.date.available | 2020-07-02T17:08:44Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0378-6471 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176620 | - |
dc.description.abstract | This study was undertaken to document the effect of transforming growth factor-β2 ( TGF-β2(TGF-β2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas bFGF increased the proliferation, TGF-β2 showed the inhibitory effect on the proliferation The inhibitory effect of TGF-β2 disappeared in RPE subcultured with 10ng/ml of bFGF. Both TGF-β2- and bFGF-specific antisense oligonucleotides blocked the autocrine effect of the growth factors. PLC-71 -specific antisense oligonucleotide inhibited the effect of TGF-β2 and bFGF. Genistein inhibited the effect of TGF-β2 and bFGF in dose-dependent man, ner. The data suggest the involvement. of in PLC-/1 and tyrosine kinase in signalling | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한안과학회 | - |
dc.relation.isPartOf | Journal of the Korean Ophthalmological Society (대한안과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | TGF-β2 및 bFGF 망막색소상피세포 증식에 미치는 영향 | - |
dc.title.alternative | The Effects of TGF-β2 and bFGF on the Proliferation of Retinal Pigment Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | 윤희성 | - |
dc.contributor.googleauthor | 노세현 | - |
dc.contributor.googleauthor | 이성철 | - |
dc.contributor.googleauthor | 정진희 | - |
dc.contributor.googleauthor | 유영현 | - |
dc.contributor.localId | A00235 | - |
dc.relation.journalcode | J01838 | - |
dc.identifier.eissn | 2092-9374 | - |
dc.contributor.alternativeName | Kwon, Oh Woong | - |
dc.contributor.affiliatedAuthor | 권오웅 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1192 | - |
dc.citation.endPage | 1203 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.36(9) : 1192-1203, 1998 | - |
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