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Alpha-fetoprotein-producing gastric cancer

Authors
 RUTH LEE  ;  SUN YOUNG RH  ;  JOONG BAE AHN  ;  KW ANG YONG SHIM  ;  JIN HYUK CHOI  ;  HO YOUNG LI  ;  NAE CHOON YOO  ;  SUNG HOON NOH  ;  JOO HANG KIM  ;  JAE KYUNG ROH  ;  JIN SIK MIN  ;  B YUNG SOO KIM  ;  HYUN CHEOL CHUNG 
Citation
 ONCOLOGY REPORTS, Vol.5(5) : 1179-1184, 1998 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
1998
MeSH
Adult ; Aged ; Female ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/epidemiology ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary* ; Male ; Middle Aged ; Neoplasm Metastasis ; Palliative Care ; Prognosis ; Stomach Neoplasms/blood* ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Survival Rate ; Time Factors ; alpha-Fetoproteins/analysis* ; alpha-Fetoproteins/biosynthesis
Abstract
We measured the sero-positivity rate of serum alpha-fetoprotein (alphaFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between alphaFP-positive and -negative patients. The overall synchronous hepatic metastasis rates in alphaFP-positive and alphaFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight alphaFP-positive patients were as follows: 37. 5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three alphaFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in alphaFP-negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in alphaFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, alphaFP can be used in predicting liver metastasis during follow-up.
Full Text
https://www.spandidos-publications.com/or/5/5/1179
DOI
10.3892/or.5.5.1179
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yoo, Nae Choon(유내춘)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176618
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