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Allelotype analysis of hepatocellular carcinoma

Authors
 Zhe Piao  ;  Chanil Park  ;  Jeon-Han Park  ;  Hoguen Kim 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.75(1) : 29-33, 1998 
Journal Title
 INTERNATIONAL JOURNAL OF CANCER 
ISSN
 0020-7136 
Issue Date
1998
MeSH
Alleles* ; Carcinoma, Hepatocellular/genetics* ; Chromosome Deletion ; Genes, Tumor Suppressor ; Genetic Markers ; Humans ; Liver Neoplasms/genetics* ; Loss of Heterozygosity*
Abstract
To elucidate the genetic events which may play important roles in hepatocarcinogenesis, we examined every non-acrocentric chromosome arm of 22 hepatocellular carcinomas (HCCs) for loss of heterozygosity (LOH) using 68 highly polymorphic microsatellite markers. Thirty-six (92%) of 39 chromosome arms showed LOH in at least one patient, however 3 chromosome arms, 2p, 2q, and 20q, did not show any LOH. High to moderate frequency of LOH (>30% of informative cases) was observed at chromosomes 1q (68.1%), 4q (72.7%), 8p (63.6%), 8q (77.3%), 10q (33.3%), 13q (40%), 14q (46.1%), 16q (59.1%), and 17p (46.2%). Among these, LOH on chromosomes 1q and 8q have not been previously identified in HCC. Our results suggest that novel tumor suppressor genes may be involved in the development and progression of HCC.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(19980105)75:1%3C29::AID-IJC5%3E3.0.CO;2-3/abstract
DOI
10.1002/(SICI)1097-0215(19980105)75:1<29::AID-IJC5>3.0.CO;2-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176617
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