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Allelotype analysis of hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2020-07-02T17:08:17Z | - |
dc.date.available | 2020-07-02T17:08:17Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176617 | - |
dc.description.abstract | To elucidate the genetic events which may play important roles in hepatocarcinogenesis, we examined every non-acrocentric chromosome arm of 22 hepatocellular carcinomas (HCCs) for loss of heterozygosity (LOH) using 68 highly polymorphic microsatellite markers. Thirty-six (92%) of 39 chromosome arms showed LOH in at least one patient, however 3 chromosome arms, 2p, 2q, and 20q, did not show any LOH. High to moderate frequency of LOH (>30% of informative cases) was observed at chromosomes 1q (68.1%), 4q (72.7%), 8p (63.6%), 8q (77.3%), 10q (33.3%), 13q (40%), 14q (46.1%), 16q (59.1%), and 17p (46.2%). Among these, LOH on chromosomes 1q and 8q have not been previously identified in HCC. Our results suggest that novel tumor suppressor genes may be involved in the development and progression of HCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alleles* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Chromosome Deletion | - |
dc.subject.MESH | Genes, Tumor Suppressor | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Loss of Heterozygosity* | - |
dc.title | Allelotype analysis of hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Zhe Piao | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Jeon-Han Park | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.identifier.doi | 10.1002/(SICI)1097-0215(19980105)75:1<29::AID-IJC5>3.0.CO;2-3 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J01092 | - |
dc.identifier.eissn | 1097-0215 | - |
dc.identifier.pmid | 94266 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(19980105)75:1%3C29::AID-IJC5%3E3.0.CO;2-3/abstract | - |
dc.contributor.alternativeName | Kim, Hogeun | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.citation.volume | 75 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | 33 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, Vol.75(1) : 29-33, 1998 | - |
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