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측두엽 간질환자에서 T2 Relaxometry의 임상적 유용성

Other Titles
 Clinical Usefulness of T2 Relaxometry in Temporal Lode Epilepsy 
 이필휴  ;  김정연  ;  김원주  ;  천영직  ;  김동익  ;  이병인 
 Journal of the Korean Neurological Association (대한신경과학회지), Vol.16(5) : 639-643, 1998 
Journal Title
 Journal of the Korean Neurological Association (대한신경과학회지) 
Issue Date
Background : Quantitative measurement of hippocampal T2 relaxation time is an objective means of determining the frequency and severity of signal abnormalities. To evaluate the diagnostic properties of T2 relaxometry in temporal lobe epilepsy(TLE), we measured T2 relaxation time of bilateral hippocampi in pathology-proven TLE patients and normal controls. Methodes : We investigated 10 TLE patients who had temporal lobectomy with MR T2 relaxation mapping. All patients underwent in phase Ⅰ orⅡ studies, and had pathologic diagnosis. Also we measured T2 relaxation time in 10 normal volunteers. Results : The pathologic findings of 10 TLE patients were followings : 8 hippocampal sclerosis (including dual pathology of necrotic granuloma), 1 calcified fibrous nodule, and 1 normal hippocampus. The mean T2 relaxation time of normal controls is 67.5msec, which is lower value than previous reports. All patients with hippocampal scleosis in pathology showed increased T2 time greater than 2 SD of mean value of normal controls. But, the T2 values are upper normal range in non-hippocampal sclerosis. The lateralizing value of T2 relaxometry is 50% in TLE patients, and 62.5% in pathology-proven hippocampal sclerosis group. Conclusions : There is a clear distinction of T2 relaxation time between the patients of hippocampal sclerosis and normal controls or non-hippocampal sclerosis. These findings suggest that the T2 relaxation time is a reliable objective measurement of hippocampal pathology, especially hippocampal sclerosis in TLE.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Lee, Byung In(이병인)
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