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Immunoreactivity of androgen receptor protein in sexually dimorphic spinal motonucleus in neonatal male rats

 Sang Won Han  ;  Koon Ho Rha  ;  Won Taik Lee  ;  Sang Yul Mah  ;  Hyung Ki Choi  ;  Seung Kang Choi 
 YONSEI MEDICAL JOURNAL, Vol.39(1) : 13-19, 1998 
Journal Title
Issue Date
Animals ; Animals, Newborn ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Androgen/analysis* ; Receptors, Androgen/immunology ; Sex Characteristics* ; Spinal Cord/chemistry*
The spinal motonucleus of the genitofemoral nerve regulating scrotal temperature can also be related to prenatal and neonatal testicular descent by gubernacular change in rats, and a sexually dimorphic-like bulbocavernosus/dorsolateral motonucleus. There is a hypothesis that neonatal androgen affects these motonuclei, and induces development of sexual organs through neural stimulation. Until now, the accumulation of isotope-labelled androgen and the immuno-reactivity of androgen receptor protein in each sexually-dimorphic spinal motonucleus have been revealed in adult rats but they have not been established in rats during neonatal periods. To investigate the presence of the androgen receptor in spinal sexually-dimorphic motonuclei in the neonatal period, we evaluated the androgen receptor immunoreactivity of these motonuclei. In Sprague-Dawley male rats, the lumbar spinal cords were resected at postnatal days 3, 10 and 30, and stained immunohistochemically using polyclonal antibody of androgen receptor protein. The immunoreactivity of androgen receptor protein was observed in the cells of the genitofemoral motonucleus from the 13th thoracic to the 2nd lumbar spinal cord and the bulbocavernosus/dorsolateral motonucleus was observed from the 4th to 5th lumbar spinal cord in all age groups. The proportional areas of both motonuclei at days 3 and 10 on cross-section were larger than at day 30. The motonuclei at days 3 and 10 were similar in all age groups. With the above results, the presence of androgen receptor protein was confirmed in the genitofemoral and bulbocavernosus/dorsolateral motonucleus from neonate to day 30. The larger proportional area of these motonuclei in neonates may indicate an active role for these motonuclei during the neonatal period. Although the immunoreactivity does not directly imply the presence of a functional receptor, neonatal androgen could be responsible for the development of sexual organs through the spinal motonucleus.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Mah, Sang Yol(마상열)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Choi, Hyung Ki(최형기)
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
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