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ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes

Authors
 Gi-Cheon Kim  ;  Choong-Gu Lee  ;  Ravi Verma  ;  Dipayan Rudra  ;  Taemook Kim  ;  Keunsoo Kang  ;  Jong Hee Nam  ;  Young Kim  ;  Sin-Hyeog Im  ;  Ho-Keun Kwon 
Citation
 FRONTIERS IN ONCOLOGY, Vol.10 : 642, 2020-05 
Journal Title
 FRONTIERS IN ONCOLOGY 
Issue Date
2020-05
Keywords
DNA methylation ; ETS1 ; breast cancer ; regulatory elements ; tumor suppressor
Abstract
ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of ETS1 in human breast cancer (BRCA) patients by investigating its expression patterns and methylation status in relation to clinical prognosis. ETS1 expression was significantly diminished by hyper-methylation of the ETS1 promoter region in specimens from BRCA patients compared to a healthy control group. Moreover, ETS1 high BRCA patients showed better prognosis and longer survival compared to ETS1 low BRCA patients. Consistent with clinical evidence, comparative transcriptome analysis combined with CRISPR/Cas9 or shRNA based perturbation of ETS1 expression revealed direct as well as indirect mechanisms of ETS1 that hinder tumorigenesis of BRCA cells. Taken together, our study enlightens a novel function of ETS1 as a tumor suppressor in breast cancer cells.
Files in This Item:
T202001671.pdf Download
DOI
10.3389/fonc.2020.00642
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho-Keun(권호근) ORCID logo https://orcid.org/0000-0003-3175-0376
Kim, Gi-Cheon(김기천)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176235
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