45세 이상 한국 남성에서 혈청 테스토스테론, 성호르몬결합글로불린 농도와 대사증후군의 관련성

Abstract

Background: This study aimed to investigate relationship between serum testosterone and sex hormone binding globulin (SHBG) levels and metabolic syndrome in Korean men aged ≥45 years old. Methods: This cross-sectional study included a total of 1,121 individuals who underwent health check-ups between November 2007 and July 2010 at the Health Promotion Center of Gangnam Severance Hospital in Seoul. Serum testosterone and SHGB levels were categorized into quartiles: Q1: ≤12.2, Q2: 12.3-15.7, Q3: 15.8-19.6, and Q4: ≥19.7 nmol/L for testosterone and Q1: ≤29.7, Q2: 29.8-39.1, Q3: 39.2-50.8, and Q4: ≥50.9 nmol/L for SHBG levels. The odds ratios and 95% confidence intervals for metabolic syndrome were calculated using multiple logistic regression analysis after adjusting for confounding factors across serum testosterone and SHGB quartiles. Results: The prevalence of metabolic syndrome gradually increased with decreasing quartiles of testosterone and SHBG levels. Compared with the highest quartile, the odds ratio the lowest quartile was 3.37 (2.21-5.13) for testosterone and 4.72 (3.02-7.38) for SHBG after adjusting for age, cigarette smoking, alcohol intake, regular exercise, hepatic enzymes, and leukocyte count. Conclusion: Serum testosterone and SHGB levels was inversely associated with metabolic syndrome in middle aged and elderly Korean males in a dose-response manner.