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Percutaneous Cryoablation in Early Stage Hepatocellular Carcinoma: Analysis of Local Tumor Progression Factors

Authors
 Dong Kyu Kim  ;  Kichang Han  ;  Jong Yun Won  ;  Gyoung Min Kim  ;  Joon Ho Kwon  ;  Man Deuk Kim 
Citation
 DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, Vol.26(2) : 111-117, 2020-03 
Journal Title
 DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY 
ISSN
 1305-3825 
Issue Date
2020-03
Abstract
Purpose: We aimed to evaluate the effectiveness and safety of percutaneous cryoablation (PC) for early or very early stage hepatocellular carcinoma (HCC) and assess the risk factors for local tumor progression (LTP) after PC. Methods: A total of 45 treatment-naïve patients treated with PC for early or very early stage HCCs were included in this retrospective study. The safety of PC was assessed by evaluating procedure-related complications and comparing hepatic function before and after the procedure. The effectiveness was assessed by evaluating technical success, LTP rates, and disease progression (DP) rates. Prognostic factors associated with LTP after PC were also analyzed. Results: Technical success and complete response were achieved in all patients (100%) by 1 month after PC. During a mean of 28.1±15.6 months of follow-up, the incidences of LTP and DP were 11.1% and 37.8%, respectively. The LTP-free and DP-free survival rates were 93.3% and 84.4% at 1 year and 88.9% and 62.2% at 2 years, respectively. Hepatic function was normalized within 3 months after PC. There were no major complications and only one minor complication of small hematoma. On univariate and multivariate analysis, minimal ablative margin <5 mm was the only significant risk factor associated with LTP. Conclusion: PC is a safe and effective therapy for patients with early or very early stage HCC. Minimal ablative margin <5 mm was a significant prognostic factor for LTP.
Files in This Item:
T202001305.pdf Download
DOI
10.5152/dir.2019.19246
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Joon Ho(권준호) ORCID logo https://orcid.org/0000-0002-6178-7252
Kim, Gyoung Min(김경민) ORCID logo https://orcid.org/0000-0001-6768-4396
Kim, Dong Kyu(김동규) ORCID logo https://orcid.org/0000-0001-7322-2550
Kim, Man Deuk(김만득) ORCID logo https://orcid.org/0000-0002-3575-5847
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Han, Ki Chang(한기창) ORCID logo https://orcid.org/0000-0002-9701-9757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176089
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