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Primary Needle-Knife Fistulotomy Versus Conventional Cannulation Method in a High-Risk Cohort of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Authors
 Sung Ill Jang  ;  Dong Uk Kim  ;  Jae Hee Cho  ;  Seok Jeong  ;  Jin-Seok Park  ;  Don Haeng Lee  ;  Chang-Il Kwon  ;  Dong Hee Koh  ;  Se Woo Park  ;  Tae Hoon Lee  ;  Hye Sun Lee 
Citation
 AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol.115(4) : 616-624, 2020-04 
Journal Title
 AMERICAN JOURNAL OF GASTROENTEROLOGY 
ISSN
 0002-9270 
Issue Date
2020-04
Abstract
Objectives: Successful biliary cannulation is a prerequisite and important component of endoscopic retrograde cholangiopancreatography, but conventional cannulation methods (CCMs) have a postendoscopic retrograde cholangiopancreatography pancreatitis (PEP) rate of 14.1% in patients at high risk for PEP. The aim of this study was to evaluate the effectiveness and safety of needle-knife fistulotomy (NKF), compared with a CCM, when used for primary biliary access in patients at high risk for developing PEP. Methods: A total of 207 patients with one or more risk factors for PEP were prospectively enrolled. The patients were randomly allocated to one of 2 groups according to the primary biliary cannulation technique (NKF or CCM). We compared biliary cannulation success rates, cannulation and procedure times, and the incidence of adverse events, including PEP, between the groups. Results: The mean number of PEP risk factors was similar between the groups (NKF, 2.2 ± 1.0; CCM, 2.2 ± 0.9). PEP occurred in 8 patients in the CCM group and in no patients in the NKF group (9.2% vs 0%, P < 0.001). The rates of other adverse events did not differ between the groups. The biliary cannulation success rate was high in the NKF group, but relatively low in the CCM group, possibly because of the stringent failure criteria aimed at reducing PEP. However, the mean cannulation and total procedural times were longer in the NKF group than in the CCM group. Discussion: NKF is an effective and safe procedure to gain primary biliary access in patients at high risk for developing PEP. ClinicalTrials.gov, NCT02916199.
Full Text
https://insights.ovid.com/crossref/00000434-202004000-00021
DOI
10.14309/ajg.0000000000000480
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Sung Ill(장성일) ORCID logo https://orcid.org/0000-0003-4937-6167
Cho, Jae Hee(조재희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176054
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