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A Novel Algorithm to Differentiate Between Multiple Primary Lung Cancers and Intrapulmonary Metastasis in Multiple Lung Cancers With Multiple Pulmonary Sites of Involvement

Authors
 Young Joo Suh  ;  Hyun-Ju Lee  ;  Pamela Sung  ;  Heera Yoen  ;  Sewoo Kim  ;  Seungchul Han  ;  Sungeun Park  ;  Jung Hee Hong  ;  Heekyung Kim  ;  Jiyeon Lim  ;  Hyungjin Kim  ;  Soon Ho Yoon  ;  Yoon Kyung Jeon  ;  Young Tae Kim 
Citation
 JOURNAL OF THORACIC ONCOLOGY, Vol.15(2) : 203-215, 2020-02 
Journal Title
 JOURNAL OF THORACIC ONCOLOGY 
ISSN
 1556-0864 
Issue Date
2020-02
Keywords
Algorithm ; Intrapulmonary metastasis ; Lung adenocarcinoma ; Multiple primary lung cancers
Abstract
Introduction: Differentiating between multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IPM) is critical for developing a therapeutic strategy to treat multiple lung cancers with multiple pulmonary sites of involvement. Methods: We retrospectively included 252 lesions (126 pairs) from 126 patients with surgically resected multiple lung adenocarcinomas. Each pair was classified as MPLC or IPM based on histopathologic findings as the reference standard. A novel algorithm was established with four sequential decision steps based on the combination of computed tomography (CT) lesion types (step 1), CT lesion morphology (step 2), difference of maximal standardized uptake values on positron-emission tomography/CT (step 3), and presence of N2/3 lymph node metastasis or distant metastasis (step 4). The diagnostic accuracy of the algorithm was analyzed. Performances of 11 observers were assessed without and with knowledge of algorithm. Results: Among 126 pairs, 90 (71.4%) were classified as MPLCs and 36 (28.6%) as IPMs. On applying the diagnostic algorithm, the overall accuracy for diagnosis of IPM among conclusive cases up to step 4 was 88.9%, and 65 and 44 pairs were correctly diagnosed based on step 1 and step 2, respectively. Specificity and positive predictive value for diagnosis of IPM increased significantly in all observers compared with reading rounds without the algorithm. Conclusions: Application of the algorithm based on comprehensive information on clinical and imaging variables can allow differentiation between MPLCs and IPMs. When both of two suspected malignant lesions appear as solid predominant lesions without spiculation or air-bronchogram on CT, IPM should be considered.
Full Text
https://www.sciencedirect.com/science/article/pii/S1556086419335622
DOI
10.1016/j.jtho.2019.09.221
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175937
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