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아산화질소 남용에 의한 척수의 아급성 연합변성 환자에서 Vitamin B12의 투여방법에 대한 체계적 고찰

Other Titles
 Systematic review of vitamin B12 regimen for patient with subacute combined degeneration of the spinal cord following nitrous oxide abuse 
Authors
 정진석  ;  좌민홍  ;  정성필  ;  박인철 
Citation
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지), Vol.17(2) : 79-85, 2019-12 
Journal Title
 Journal of the Korean Society of Clinical Toxicology (대한임상독성학회지) 
ISSN
 1738-1320 
Issue Date
2019-12
Keywords
Subacute combined degeneration ; Nitrous oxide ; Inhalant abuse ; Vitamin B12
Abstract
Purpose: The purpose of this study is to evaluate the effectiveness of vitamin B12 treatment in subacute combined degeneration (SCD) caused by nitrous oxide (N2O) abuse. Methods: Relevant literature was accessed through PubMed, EMBASE, Scopus, and KoreaMed. All the literature that was relevant to human use of vitamin B12 treatment for SCD caused by N2O abuse was included. Case reports were excluded if the treatment regimens were not precisely described. The literature search was conducted by two investigators during September 2019 for the final publication period. The languages of the publications were restricted to English and Korean. Results: Twenty-three published articles that contained 24 cases were included. Sixteen cases among them were treated with intramuscular vitamin B12 of 1 mg/day and the rest received different doses or routes. Although most cases described significant clinical improvements, one case showed no beneficial effect due to the patient’s noncooperation. Another case showed adverse events, including spinal myoclonus, following vitamin B12 therapy. Conclusion: Vitamin B12 has been broadly used for the treatment of SCD caused by N2O abuse. However, most of the relevant studies were case reports that reported various regimens of vitamin B12 administration. Further studies are needed to establish a standard regimen of vitamin B12 because the incidence of N2O abuse may increase in South Korea.
Files in This Item:
T201906302.pdf Download
DOI
10.22537/jksct.17.2.79
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Park, In Cheol(박인철) ORCID logo https://orcid.org/0000-0001-7033-766X
Chung, Sung Phil(정성필) ORCID logo https://orcid.org/0000-0002-3074-011X
Choa, Min Hong(좌민홍) ORCID logo https://orcid.org/0000-0003-0338-994X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175914
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