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Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination

Authors
 Min Jung Kim  ;  Doo Hee Shim  ;  Hye-Ran Cha  ;  Cheong Bi Kim  ;  Soo Yeon Kim  ;  Jeon Han Park  ;  Myung Hyun Sohn  ;  Jae Myun Lee  ;  Kyung Won Kim 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.12(2) : 359-363, 2020 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2020
Keywords
Anaphylaxis ; delayed hypersensitivity ; drug hypersensitivity ; immunoglobulin E ; influenza ; vaccination ; vaccines
Abstract
Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although the safety of influenza vaccines has been well documented, occasional cases of anaphylaxis in vaccinated patients have been reported. In this study, we analyzed the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric case of delayed-onset anaphylaxis after influenza vaccination. The patient showed elevated specific IgE levels against whole influenza vaccines, especially with split virion from egg-based manufacturing process. Specific IgE levels to influenza vaccines showed decreased over. We evaluated a causal relationship between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent assay. Delayed-onset anaphylaxis after influenza vaccination can occur in children without predisposing allergic diseases. In addition, the results suggested that formulation and production system of influenza vaccines could affect the probability of severe allergic reaction to vaccines.
Files in This Item:
T202000757.pdf Download
DOI
10.4168/aair.2020.12.2.359
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Kim, Soo Yeon(김수연) ORCID logo https://orcid.org/0000-0003-4965-6193
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Shim, Doo Hee(심두희) ORCID logo https://orcid.org/0000-0002-6696-7199
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175574
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