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Association between non-alcoholic fatty liver disease and coronary calcification depending on sex and obesity

 Seok-hyung Kim  ;  Hae Yeul Park  ;  Hye Sun Lee  ;  Kwon Soo Jung  ;  Moon Hyoung Lee  ;  Jong Hyun Jhee  ;  Tae Hoon Kim  ;  Jung Eun Lee  ;  Hyung Jong Kim  ;  Beom Seok Kim  ;  Hyeong Cheon Park  ;  Byoung Kwon Lee  ;  Hoon Young Choi 
 SCIENTIFIC REPORTS, Vol.10(1) : 1025, 2020 
Journal Title
Issue Date
Non-alcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome and is associated with cardiovascular outcomes. We investigated whether NAFLD was associated with coronary artery calcification (CAC) in participants without a previous history of cardiovascular disease and whether this association differed according to sex and obesity status after adjustment for other atherosclerosis risk factors, alcohol intake, and liver enzyme levels. Among 67,441 participants, data from 8,705 participants who underwent a fatty liver status and CAC assessment during routine health screening were analysed. CAC scores were calculated using computed tomography. NAFLD was diagnosed in patients with evidence of liver steatosis on ultrasonography. Obesity was defined as a body mass index of ≥25 kg/m2. Multivariate analysis showed a significant association between NAFLD and CAC in non-obese participants (odds ratio, 1.24 [95% confidence interval, 1.01-1.53]), whereas NAFLD and CAC were not associated in obese participants. Interaction analysis showed that the association between NAFLD and CAC was influenced by sex and obesity. Subgroup analysis revealed a significant association between NAFLD and CAC in non-obese male participants (odds ratio, 1.36 [1.07-1.75]), but not in female participants. Our study indicates that non-obese men with NAFLD are prone to CAC.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Park, Hae Yeul(박해열)
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Lee, Moon Hyoung(이문형)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Jung, Kwon Soo(정권수) ORCID logo https://orcid.org/0000-0003-3238-5139
Jhee, Jong Hyun(지종현)
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
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