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Vessels Encapsulating Tumor Clusters (VETC) Is a Powerful Predictor of Aggressive Hepatocellular Carcinoma

DC Field Value Language
dc.contributor.author박영년-
dc.contributor.author우하영-
dc.contributor.author이형진-
dc.contributor.author이혜선-
dc.date.accessioned2020-02-26T06:41:12Z-
dc.date.available2020-02-26T06:41:12Z-
dc.date.issued2020-
dc.identifier.issn0270-9139-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175250-
dc.description.abstractWe investigated the clinical significance of a vascular growth pattern of hepatocellular carcinoma (HCC), the vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination. VETC was assessed in a large multi-institutional cohort of 541 resected HCCs from Italy, Korea and Japan, and matched against a full spectrum of clinical and pathological variables. The VETC phenotype (defined as ≥ 55% tumor area by CD34 immunostaining) was easily reproducible and reliably detectable in whole sections and small-sized tissues of tissue microarray. VETC HCCs represented 18.9% of the whole series, the lowest proportion occurring in the cohort with smallest tumors (8.7%, Japanese series). VETC was significantly associated with several clinical and pathological features such as high alfa-fetoprotein (AFP) level, tumor size greater than 5 cm, poor differentiation, macrotrabecular pattern, less compact pattern, less inflammatory infiltrates, and frequent microvascular invasion. VETC was associated with early recurrence (hazard ratio [HR]: 1.52 [1.06-2.19], P = 0.023), disease-free survival (HR: 1.66 [1.21-2.27], P = 0.002), and overall survival (HR: 2.26 [1.37-3.72], P = 0.001) at multivariable analysis. VETC affected the survival in HCC patients stratified for etiology (hepatitis C virus/hepatitis B virus), vascular invasion, and specific molecular phenotypes (β-catenin/GS+). This distinct vascular pattern was enriched in the recently reported macrotrabecular massive HCC subtype, which was seen in 7.8% (42 of 541) of patients and associated with high AFP levels and poor differentiation. Conclusion: The VETC pattern was found to be easily detectable in a consistent fraction of HCC and a powerful pathological finding affecting survival. This study suggests that the heterogeneous pattern of angiogenesis is involved in HCC behavior.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfHEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleVessels Encapsulating Tumor Clusters (VETC) Is a Powerful Predictor of Aggressive Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSalvatore Lorenzo Renne-
dc.contributor.googleauthorHa Young Woo-
dc.contributor.googleauthorSarah Allegra-
dc.contributor.googleauthorNoemi Rudini-
dc.contributor.googleauthorHirohisa Yano-
dc.contributor.googleauthorMatteo Donadon-
dc.contributor.googleauthorLuca Viganò-
dc.contributor.googleauthorJun Akiba-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHyungjin Rhee-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorMassimo Roncalli-
dc.contributor.googleauthorLuca Di Tommaso-
dc.identifier.doi10.1002/hep.30814-
dc.contributor.localIdA01563-
dc.contributor.localIdA04854-
dc.contributor.localIdA05171-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ00985-
dc.identifier.eissn1527-3350-
dc.identifier.pmid31206715-
dc.identifier.urlhttps://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.30814-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor우하영-
dc.contributor.affiliatedAuthor이형진-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume71-
dc.citation.number1-
dc.citation.startPage183-
dc.citation.endPage195-
dc.identifier.bibliographicCitationHEPATOLOGY, Vol.71(1) : 183-195, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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