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Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis

Authors
 Doo Hee Shim  ;  Thuy Trang Nguyen  ;  Pil-gu Park  ;  Min Jung Kim  ;  Byung-wook Park  ;  Hye-Rin Jeong  ;  Dae-Sung Kim  ;  Hyun Woo Joo  ;  Seong-O Choi  ;  Jung-Hwan Park  ;  Jae Myun Lee 
Citation
 MOLECULAR PHARMACEUTICS, Vol.16 : 4913-4919, 2019 
Journal Title
 MOLECULAR PHARMACEUTICS 
ISSN
 1543-8384 
Issue Date
2019
Keywords
botulinum toxin A ; hyperhidrosis ; microneedles
Abstract
Hyperhidrosis is a disorder that is characterized by the production of excess amounts of sweat. The botulinum neurotoxin A (BoNT/A) has been used to treat hyperhidrosis through multiple intradermal injections at the site of the condition. However, because of BoNT/A toxicity, it is important to precisely deliver the proper dose of the toxin to the target site. In addition, the use of a conventional hypodermic needle for multiple injections in the palm makes the approach undesirable and painful. Here, we designed a BoNT/A-coated microneedle (BoNT-MN) array and tested its efficacy as a substitute pain-free method to treat hyperhidrosis. BoNT-MNs were prepared by coating polylactic acid microneedles with a BoNT/A formulation and were found to successfully penetrate into a thick skin in vitro. The coating formulations were then tested for their stability at 4, 25, and 37 °C for 24 h. BoNT-MNs were found to be much more stable than BoNT/A in a liquid state. Additionally, we carried out in vivo experiments by treating the right paws of mice with BoNT-MNs and found that the treatment induced a significant reduction in the sweating response in the mouse foot pad. Thus, BoNT/A treatment using microneedles is beneficial and may be used as a more efficient and less painful approach to treat hyperhidrosis.
Full Text
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00794
DOI
10.1021/acs.molpharmaceut.9b00794
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0002-5634-9709
Park, Pil Gu(박필구) ORCID logo https://orcid.org/0000-0002-3024-3439
Shim, Doo Hee(심두희) ORCID logo https://orcid.org/0000-0002-6696-7199
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174614
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