0 91

Cited 0 times in

Sox2 maintains epithelial cell proliferation in the successional dental lamina

 Eun‐Jung Kim  ;  Seo‐Yoon Jung  ;  Zhaoming Wu  ;  Sushan Zhang  ;  Han‐Sung Jung 
 CELL PROLIFERATION, Vol.53(1) : e12729, 2020-01 
Journal Title
Issue Date
Claudin10 ; Laminin5 ; Sox2 ; cell proliferation ; successional dental lamina
OBJECTIVES: The successional dental lamina is the distinctive structure on the lingual side of the vertebrate tooth germ. The aim of this study was to investigate the relationship among Sox2, Claudin10 and laminin5 and the role of Sox2 in successional dental lamina proliferation during vertebrate tooth development. MATERIALS AND METHODS: To understand the successional dental lamina, two types of successional tooth formation, that in geckos (with multiple rounds of tooth generation) and that in mice (with only one round of tooth generation), were analysed. RESULTS: Unique coexpression patterns of Sox2 and Claudin10 expression were compared in the successional dental lamina from the cap stage to the late bell stage in the mouse tooth germ and in juvenile gecko teeth to support continuous tooth replacement. Furthermore, Laminin5 expression was shown in the cap stage and decreased after the bell stage. Upon comparing the epithelial cell cycles and cell proliferation in successional dental lamina regions between mouse and gecko molars using BrdU and IdU staining and pulse-chase methods, distinctive patterns of continuous expression were revealed. Moreover, Sox2 overexpression with a lentiviral system resulted in hyperplastic dental epithelium in mouse molars. CONCLUSIONS: Our findings indicate that the regulation of Sox2 in dental lamina proliferation is fundamental to the successional dental lamina in both species.
Full Text
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.