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골 육종의 단순 방사선 사진과 자기공명영상 사진의 부피계측에서 재현성의 비교

Other Titles
 Comparison of Reproducibility in Volume Measurement with Plain Radiograph and Magnetic Resonance Imaging of Osteosarcoma 
Authors
 문성환  ;  신규호  ;  서진석  ;  한수봉 
Citation
 Journal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.34(6) : 1035-1040, 1999 
Journal Title
 Journal of the Korean Orthopaedic Association (대한정형외과학회지) 
ISSN
 1226-2102 
Issue Date
1999
Keywords
Osteosarcoma ; Volume measurement ; Reproducibility ; MRI
Abstract
Purpose: The volumetric change of osteosarcoma after preoperative adjuvant chemotherapy is a significant prognostic factor. It is absolutely necessary that al1 volumetric measurements must be based on acceptable reproducibility. The purpose of this study was to investigate intra- and inter-observer variability of volumetric measurements, including plain radiography and magnetic resonance image (MRI). Materials and Methods: Forty-one patients with osteosarcoma of the limb were included in this study. All patients underwent plain radiographs and MRIs before and after preoperative adjuvant chemotherapy (intraarterial Cisplatin and intravenous Adriamycn, 3 cycles). Volume measurement, using ellipsoid formula from maximal length width and depth of the tumor on plain radiograph and MRI, were calculated. Three dimensional summation of the tumor volume from MRI, with digitized scanner and software (MatLab. MatWork Inc, Natick, MA, USA) was also performed. Coefficient of variation (CV) of each method was compared. Results: CVs for intra- and inter-observer variability in plain radiograph using ellipsoid formula were 9.4% and 11.7% in prechemotherapy and 8.1% and 9.3% in post chematherapy. CVs for intra- and inter-observer variability in MRI using ellipsoid formula were 7.3% and 7.9% in prechemotherapy, and 7.6% and 8.2% in postchemotherapy in Tl weighted image (T1WI), 6.7% and 7.1% in prechemotherapy and 6.5% and 7.6% in postchemotherapy in T2 weighted image (T2WI), and 7.8% and 8.5% in prechemotherapy and 8.2% and 8.7!o in postchemotherapy in Gd-DTPA enhanced image (GdEI) . CVs for intra- and inter-observer vanability in MRI using three dimensional summation of tumor volume were 2.4% and 3.2% in prechemotherpay and 2.7% and 3.4% in postchemotherapy in T1WI, 1.2% and 1.4% in prechemotherapy and 1.3% and 1.4% in postchemotherapy in T2WI, and 3.8% and 4.5% in prechemotherapy and 3.1% and 4.6% in postchemotherapy in GdEI. Conclusion: There was higher reproducibility, that is lower CV, in three dimensional summation of tumor volume in T2WI The statistically significant volume change after chemotherapy was 4.2% decrease or increase in volume compared with its original tumor volume in T2WI.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seong Hwan(문성환)
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Shin, Kyoo Ho(신규호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174410
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