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Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment

 Ulf M. E. Wikesjö  ;  Paola Guglielmoni  ;  Ananya Promsudthi  ;  Kyoo‐Sung Cho  ;  Leonardo Trombelli  ;  Knut A. Selvig  ;  Lisa Jin  ;  John M. Wozney 
 Journal of Clinical Periodontology, Vol.26(6) : 392-400, 1999 
Journal Title
 Journal of Clinical Periodontology 
Issue Date
Absorbable Implants ; Alveolar Bone Loss/drug therapy* ; Alveolar Bone Loss/surgery ; Animals ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins/adverse effects ; Bone Morphogenetic Proteins/pharmacology* ; Bone Morphogenetic Proteins/therapeutic use ; Bone Regeneration/drug effects* ; Cattle ; Collagen ; Dental Cementum/drug effects* ; Dental Implantation, Endosseous/methods ; Dental Implants ; Dogs ; Humans ; Implants, Experimental ; Male ; Mandible ; Periodontal Attachment Loss/drug therapy* ; Periodontal Attachment Loss/surgery ; Recombinant Proteins/pharmacology ; Regeneration/drug effects* ; Root Resorption/etiology ; Tooth Ankylosis/etiology ; Transforming Growth Factor beta*
The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) concentration on regeneration of alveolar bone and cementum, and on associated root resorption and ankylosis. Contralateral, critical size, supra-alveolar, periodontal defects were surgically produced and immediately implanted with rhBMP-2 in an absorbable collagen sponge (ACS) carrier in 8, young adult, male, beagle dogs. 6 animals received rhBMP-2/ACS (rhBMP-2 at 0.05, 0.10, or 0.20 mg/mL; total construct volume/defect approximately 4.0 mL) in contralateral defects following an incomplete block design. 2 animals received rhBMP-2/ACS (rhBMP-2 at 0 and 0.10 mg/mL) in contralateral defects (controls). The animals were euthanised at 8 weeks post-surgery and block sections of the defects were collected for histologic and histometric analysis. Supra-alveolar periodontal defects receiving rhBMP-2 at 0.05, 0.10, or 0.20 mg/ml exhibited extensive alveolar regeneration comprising 86%, 96%, and 88% of the defect height, respectively. Cementum regeneration encompassed 8%, 6%, and 8% of the defect height, respectively. Root resorption was observed for all rhBMP-2 concentrations. Ankylosis was observed in almost all teeth receiving rhBMP-2. Control defects without rhBMP-2 exhibited limited, if any, evidence of alveolar bone and cementum regeneration, root resorption, or ankylosis. Within the selected rhBMP-2 concentration and observation interval, there appear to be no meaningful differences in regeneration of alveolar bone and cementum. There also appear to be no significant differences in the incidence and extent of root resorption and ankylosis, though there may be a positive correlation with rhBMP-2 concentration.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
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