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고춧가루와 Capsaicin 이 위배출에 미치는 영향

Other Titles
 The Effect of Red Pepper and Capsaicin on Gastric Emptying 
Authors
 나상규  ;  박효진  ;  정대호  ;  김정호  ;  김기황  ;  이송미  ;  윤선  ;  이상인  ;  박인서 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.33(4) : 496-503, 1999 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
1999
Keywords
Capsaicin ; Red pepper ; Gastric emptying
Abstract
Background/Aims: Capsaicin stimulates the release of several neuropeptides and has diverse effects on gastrointestinal function. We investigated the effect of intragastric red pepper or capsaicin on the gastric emptying in human. Methods: Fourteen healthy male volunteers were recruited. Gastric emptying was assessed by radio-opaque markers (ROMs) method and plasma acetaminophen (AAP) levels. Results: The clearance of ROMs at 2 hours and 3 hours was 10.6 ±15.9 and 73.1 ±34.6% after administration of placebo, 17.6 ±26.0 and 78.7 ±40.2% after administration of red pepper 3 g 27.8 ±34.0 and 73.2 ±31.9% after administration of red pepper 6 g, 2.1 ±5.1 and 15.5 ±20.7% afte administration of capsaicin 17.3 mg. Capsaicin significantly delayed the gastric emptying of ROMs The serum AAP concentrations were measured at 30, 45, 60, 75 and 90 min after administration o placebo (4.09 ±3.45, 8.09 ±4.13, 13.55 ±4.90, 15.50 ±3.44 and 13.0 ±7.53 μg/ml), red pepper 3 g (5.63 ±4.84, 8.88 ±4.76, 14.25 ±5.01, 15.11 ±5.16 and 16.80 ±6.57 μg/ml), red pepper 6 g (7.0 ± 7.19, 8.09 ±5.63, 12.09 ±6.04, 13.73 ±4.65 and 14.28 ±3.77 μg/ml), capsaicin 17.3 mg (4.50 ±2.88 , 7.17 ±3.19, 11.50 ±4.76, 11.17 ±3.71 and 13.33 ±3.72 μg/ml). Intragastric red pepper or capsaicin made no significant difference of serum acetaminophen level from placebo. Conclusions: Intragastric administration of capsaicin delayed gastric emptying of indigestible solid meal, whereas red pepper did not. The gastric emptying of liquid meal was affected by neither capsaicin nor red pepper.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174304
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