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Role of the inflamed synovial volume of the wrist in defining remission of rheumatoid arthritis with gadolinium-enhanced 3D-SPGR MR imaging

 Yong‐min Huh  ;  Jin‐suck Suh  ;  Eun‐kee Jeong  ;  Soo‐kon Lee  ;  Ji‐soo Lee  ;  Byong‐Wook Choi  ;  Dong Kee Kim 
 Journal of Magnetic Resonance Imaging, Vol.10(2) : 202-208, 1999 
Journal Title
 Journal of Magnetic Resonance Imaging 
Issue Date
Adult ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis* ; Arthritis, Rheumatoid/drug therapy ; Female ; Follow-Up Studies ; Gadolinium DTPA* ; Humans ; Magnetic Resonance Imaging/methods* ; Magnetic Resonance Imaging/statistics & numerical data ; Male ; Middle Aged ; Observer Variation ; Remission Induction ; Statistics, Nonparametric ; Synovitis/diagnosis* ; Synovitis/drug therapy ; Time Factors ; Wrist Joint
The purpose of this study was to assess the role of inflamed synovial volume (ISV) in defining a state of remission in rheumatoid arthritis (RA) with contrast-enhanced, fat-suppression, three-dimensional (3D) gradient-recalled acquisition in the steady state with radiofrequency spoiling (SPGR) magnetic resonance (MR) imaging. Sixteen patients with RA (5 remission and 11 non-remission patients) were enrolled in this study. Contrast-enhanced, fat-suppression, 3D-SPGR MR imaging was performed before (n = 12) and after (n = 16) a mean 17 months of disease-modifying antirheumatic drugs (DMARDs). ISV was calculated by using a segmentation method. Statistical analysis of changes in ISVs and residual ISVs between the remission and the non-remission groups was performed. Intra- and inter-observer reproducibility was tested. Residual ISVs and relative changes in ISVs were 3.23 +/- 1.84 cm(3) and 51.4% (range 47.6-55.2%) in the remission group and 6.26 +/- 2. 03 cm(3)and 31.4% (range -73.5-53.5%) in the non-remission group. Both values were significantly different between the two groups (P < 0.05 and 0.05, respectively). Volume measurement showed high reproducibility: Intra- and inter-observer mean percentage errors were 5.04, 7.06, and 5.09%, respectively. Residual ISVs and relative changes in ISVs measured by MR imaging may provide objective and quantitative parameters in defining a state of remission in RA after therapy; however, the clinical utility of these measurements remains to be verified.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lee, Soo Kon(이수곤)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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