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Prognostic significance of CD44 and nm23 expression in patients with stage II and stage IIIA gastric carcinoma

Authors
 Chang Hak Yoo  ;  Sung Hoon Noh  ;  Hoguen Kim  ;  Han Young Lee  ;  Jin Sik Min 
Citation
 Journal of Surgical Oncology, Vol.71(1) : 22-28, 1999 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
1999
MeSH
Adult ; Aged ; Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/analysis ; Female ; Humans ; Hyaluronan Receptors/metabolism* ; Immunohistochemistry ; Male ; Middle Aged ; Monomeric GTP-Binding Proteins* ; Multivariate Analysis ; NM23 Nucleoside Diphosphate Kinases ; Neoplasm Staging ; Nucleoside-Diphosphate Kinase* ; Prognosis ; Stomach Neoplasms/chemistry ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology* ; Survival Rate ; Transcription Factors/metabolism*
Abstract
BACKGROUND AND OBJECTIVES: Predicting the prognosis in gastric carcinoma patients with intermediate stages is difficult. We investigated the prognostic impacts of CD44 and nm23 expression in a homogeneous group of patients with stage II and IIIA gastric carcinoma who had undergone curative resections. METHODS: A total of 261 paraffin-embedded gastric carcinomas were stained with the monoclonal antibodies CD44 and nm23 using the labeled streptovidin biotin method. RESULTS: The expression of CD44 and nm23 was detected, respectively, in 31.0% (81/261) and 70.1% (183/261) of all tumors. There was no correlation between CD44 expression and clinicopathological variables. However, nm23 was more frequently expressed in older patients with differentiated adenocarcinoma. A significant difference in 5-year survival rates was found between patients with CD44-positive (43.2%) and CD44-negative tumors (63.4%), (P = 0.0018). However, there was no significant difference in 5-year survival rates between patients with nm23-positive (54.7%) and nm23-negative tumors (62.7%) (P = 0.2734). CONCLUSIONS: CD44 expression was a significant adverse prognostic factor in gastric carcinoma and may be a predictor of metastatic potential of the primary tumor. By contrast, immunohistochemical detection of nm23 expression was not a predictor of outcome of patients with gastric carcinoma.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9098%28199905%2971%3A1%3C22%3A%3AAID-JSO5%3E3.0.CO%3B2-I
DOI
10.1002/(sici)1096-9098(199905)71:1<22::aid-jso5>3.0.co;2-i
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174159
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