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Prognostic significance of CD44 and nm23 expression in patients with stage II and stage IIIA gastric carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 노성훈 | - |
dc.date.accessioned | 2020-01-23T05:17:27Z | - |
dc.date.available | 2020-01-23T05:17:27Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174159 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Predicting the prognosis in gastric carcinoma patients with intermediate stages is difficult. We investigated the prognostic impacts of CD44 and nm23 expression in a homogeneous group of patients with stage II and IIIA gastric carcinoma who had undergone curative resections. METHODS: A total of 261 paraffin-embedded gastric carcinomas were stained with the monoclonal antibodies CD44 and nm23 using the labeled streptovidin biotin method. RESULTS: The expression of CD44 and nm23 was detected, respectively, in 31.0% (81/261) and 70.1% (183/261) of all tumors. There was no correlation between CD44 expression and clinicopathological variables. However, nm23 was more frequently expressed in older patients with differentiated adenocarcinoma. A significant difference in 5-year survival rates was found between patients with CD44-positive (43.2%) and CD44-negative tumors (63.4%), (P = 0.0018). However, there was no significant difference in 5-year survival rates between patients with nm23-positive (54.7%) and nm23-negative tumors (62.7%) (P = 0.2734). CONCLUSIONS: CD44 expression was a significant adverse prognostic factor in gastric carcinoma and may be a predictor of metastatic potential of the primary tumor. By contrast, immunohistochemical detection of nm23 expression was not a predictor of outcome of patients with gastric carcinoma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | Journal of Surgical Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, Neoplasm/metabolism | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronan Receptors/metabolism* | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monomeric GTP-Binding Proteins* | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | NM23 Nucleoside Diphosphate Kinases | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Nucleoside-Diphosphate Kinase* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Stomach Neoplasms/chemistry | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.title | Prognostic significance of CD44 and nm23 expression in patients with stage II and stage IIIA gastric carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Chang Hak Yoo | - |
dc.contributor.googleauthor | Sung Hoon Noh | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Han Young Lee | - |
dc.contributor.googleauthor | Jin Sik Min | - |
dc.identifier.doi | 10.1002/(sici)1096-9098(199905)71:1<22::aid-jso5>3.0.co;2-i | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01281 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 10362087 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9098%28199905%2971%3A1%3C22%3A%3AAID-JSO5%3E3.0.CO%3B2-I | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.citation.volume | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 22 | - |
dc.citation.endPage | 28 | - |
dc.identifier.bibliographicCitation | Journal of Surgical Oncology, Vol.71(1) : 22-28, 1999 | - |
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