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Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage

Authors
 Jeong-Sook SUH  ;  Jae-Soon EUN  ;  June-No SO  ;  Jeong-Taeg SEO  ;  Gil-Ja JHON 
Citation
 Biological & Pharmaceutical Bulletin, Vol.22(9) : 932-935, 1999 
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN
 0918-6158 
Issue Date
1999
MeSH
Animals ; Antlers/chemistry* ; Calcium/metabolism ; Deer ; Ethanol/chemistry ; Macrophages, Peritoneal/drug effects* ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Nitric Oxide/metabolism ; Phagocytosis/drug effects* ; Tissue Extracts/pharmacology*
Abstract
The mechanism of phagocytic activity of the ethyl alcohol fraction of Cervus nippon (CN-E) was investigated in vivo. The administration of CN-E (100 mg/kg, p.o.) enhanced lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles in murine peritoneal macrophages. Phagocytic activity was suppressed by the treatment of S-nitrosoglutathione (GSNO) which is an exogenous nitric oxide donor depending on the concentration of dose. CN-E suppressed the production of nitric oxide and enhanced the concentration in [Ca2+]i. The enhancement in [Ca2+]i was diminished by the treatment of EGTA. These results indicate that CN-E enhances the phagocytic activity of murine peritoneal macrophage via a suppression of nitric oxide production and an increase in [Ca2+]i.
Files in This Item:
T199902043.pdf Download
DOI
10.1248/bpb.22.932
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174115
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