Cited 26 times in
Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서정택 | - |
dc.date.accessioned | 2020-01-23T05:14:32Z | - |
dc.date.available | 2020-01-23T05:14:32Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174115 | - |
dc.description.abstract | The mechanism of phagocytic activity of the ethyl alcohol fraction of Cervus nippon (CN-E) was investigated in vivo. The administration of CN-E (100 mg/kg, p.o.) enhanced lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles in murine peritoneal macrophages. Phagocytic activity was suppressed by the treatment of S-nitrosoglutathione (GSNO) which is an exogenous nitric oxide donor depending on the concentration of dose. CN-E suppressed the production of nitric oxide and enhanced the concentration in [Ca2+]i. The enhancement in [Ca2+]i was diminished by the treatment of EGTA. These results indicate that CN-E enhances the phagocytic activity of murine peritoneal macrophage via a suppression of nitric oxide production and an increase in [Ca2+]i. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pharmaceutical Society of Japan | - |
dc.relation.isPartOf | Biological & Pharmaceutical Bulletin | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antlers/chemistry* | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Deer | - |
dc.subject.MESH | Ethanol/chemistry | - |
dc.subject.MESH | Macrophages, Peritoneal/drug effects* | - |
dc.subject.MESH | Macrophages, Peritoneal/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Phagocytosis/drug effects* | - |
dc.subject.MESH | Tissue Extracts/pharmacology* | - |
dc.title | Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jeong-Sook SUH | - |
dc.contributor.googleauthor | Jae-Soon EUN | - |
dc.contributor.googleauthor | June-No SO | - |
dc.contributor.googleauthor | Jeong-Taeg SEO | - |
dc.contributor.googleauthor | Gil-Ja JHON | - |
dc.identifier.doi | 10.1248/bpb.22.932 | - |
dc.contributor.localId | A01905 | - |
dc.relation.journalcode | J00300 | - |
dc.identifier.eissn | 1347-5215 | - |
dc.identifier.pmid | 10513615 | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | 서정택 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 932 | - |
dc.citation.endPage | 935 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, Vol.22(9) : 932-935, 1999 | - |
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