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인터페론 단독 투여에 지속적 치료 효과가 없었던 만성 C 형 간염 환자에서의 인터페론과 리바비린의 병용 치료

Other Titles
 Combined Treatment with Interferon Alpha and Ribavirin for Chronic Hepatitis C in Patients with Previous Non-response or Relapse to Interferon Alone 
 이천균  ;  한광협  ;  정정일  ;  최원  ;  최병현  ;  김부일  ;  이관식  ;  전재윤  ;  문영명  ;  김영아  ;  김현숙 
 Korean Journal of Gastroenterology, Vol.33(2) : 232-239, 1999 
Journal Title
Korean Journal of Gastroenterology(대한소화기학회지)
Issue Date
Chronic C viral hepatitis ; Interferon alpha ; Ribavirin ; Non-response and relapse
Background/Aims: Interferon-alpha has been effective in 10-20% of treated patients with chronic hepatitis C (CH-C) on a long term basis. We conducted this study to evaluate the biochemical and virological outcomes of combined treatment with interferon alpha and ribavirin for the patients who had CH-C but showed non-response or relapse to interferon alpha alone. Methods: Twenty five patients with CH-C who had not responded or relapsed to interferon alpha alone treatment were enrolled. Eighteen patients were given by the combined treatment of interferon alpha and ribavirin and 7 patients were not given any specific treatment as control. Interferon alpha-2a was given subcutaneously, at a dose of 4.5 MU thrice weekly. Ribavirin was also given orally, at a dose of 900 mg/day for 24 weeks. We quantified serum HCV-RNA levels at the end of treatment. Results: The normalization rate of serum ALT at the end of treatment was 47.1% (8/17) in treated group and 14.3% (1/7) in control group and negative conversion of HCV-RNA was noted in all patients. In the treated group, 75% (6/8) of responders at the end of treatment sustained serum ALT level normally during 24 weeks follow-up, but none has responded persistently in the control group. Conclusions The combined treatment with interferon alpha and ribavirin is effective and safe for treating chronic hepatitis C in patients who showed non-response or relapse to interferon alone.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
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