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T1 강조 자기공명영상에서 고신호강도를 보이는 국소 간결절 : 다중시기 조영증강 역동자기공명영상에서 정량적 분석을 통한 소간세포암과 이형성결절의 감별

Other Titles
 Focal Hepatic Nodules with High Signal Intensity on T1-weighted MR Imaging: Differentiation of Small Hepatocellular Carcinoma from Dysplastic Nodule by Quantitative Analysis of Multi-phase Contrast-enhanced DynamicMR Imaging 
 이광훈  ;  유정식  ;  김기황  ;  조나리야  ;  정미경  ;  김재근 
 Journal of the Korean Radiologist Society (대한방사선의학회지), Vol.40(6) : 1153-1158, 1999 
Journal Title
Journal of the Korean Radiologist Society(대한방사선의학회지)
Issue Date
Liver neoplasms ; Liver, MR
PURPOSE: To evaluate the usefulness of quantitative analysis of the degree of enhancement in dynamic MRimaging used to differentiate dysplastic nodule (DN) from small hepatocellular carcinoma (HCC), both of which showhigh signal intensity on T1-weighted images. MATERIALS AND METHODS: From 26 small HCCs and 71 DNs, all of whichshowed homogeneous high signal intensity on T1-weighted images among 42 patients with liver cirrhosis, weselected 16 small HCCs and 10 DNs of more than 1cm in diameter which were diagnosed by biopsy and follow-up imaging. Dynamic MR imaging of the entire liver was obtained using the breath-hold technique at postinjection 10sec. (phase 1), 35 sec. (phase 2), 60 sec. (phase 3), and 5 min. (delayed) after intravenous manual injection ofGd-DTPA (0.1 mmol/kg) at a velocity of 3-4 cc/sec. Nodule-to-liver contrast-to-noise ratios (CNR) during eachphase were calculated by measurement of the region of interest. RESULTS: On precontrast T1-weighted images, themean CNR of small HCCs was 2.873, and that of DNs was 3.854, there was thus no significant statistical difference(p>0.01). On postcontrast images, the CNR of small HCCs during each phase was 5.565, 3.790, 1.704, and 1.282, withpeak CNR phase 1 and a mostly decreasing trend thereafter. However, the CNR of DNs during each phase was 3.053,1.561, 0.919, and 1.038 ; there was thus showed no significant increase during phase 1 in comparison with the CNRsseen on precontrast images. During the precontrast stage and phase 1, the average difference in CNR was 2.691 forsmall HCCs and 0.801 for DNs the difference was thus significant (p<0.01). CONCLUSION: Quantitative analysis ofCNR, reflecting the degree of nodule-to-liver enhancement in dynamic MR imaging, was found to be useful for thedifferentiation of small HCCs from DNs, both of which show high signal intensity on T1-weighted images.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
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