15 42

Cited 0 times in

비소세포성 폐암 환자에서 Proliferating Cell Nuclear Antigen, c-erb B-2 및 c-fos 단백질 발현과 예후와의 상관관계

Other Titles
 Prognostic Value of PCNA , c-erbB-2 , c-fos in Patients with Non-small Cell Lung Cancer 
Authors
 이이형  ;  안중배  ;  신동환  ;  홍순원  ;  심정연  ;  정경영  ;  김세규  ;  장준  ;  김주항  ;  이원영  ;  김병수  ;  김성규 
Citation
 Journal of the Korean Cancer Association (대한암학회지), Vol.31(4) : 678-685, 1999 
Journal Title
 Journal of the Korean Cancer Association (대한암학회지) 
ISSN
 0496-6872 
Issue Date
1999
Keywords
Lung cancer ; PCNA ; c-erbB-2 ; c-fos
Abstract
PURPOSE: Oncogenes, tumor suppressor genes, and growth variables of tumors are important in the assessment of prognosis in lung cancer. The expression of PCNA, c-erbB-2 (HER-2/neu), and c-fos oncoprotein and their prognostic implications in surgically resected patients with non-small cell lung cancer were evaluated. MATERIALS AND METHODS: Seventy patients with non-small cell lung cancer were included and PCNA, c-erbB-2 and c-fos overexpression were evaluated by immunohistochemical stain using paraffin-embedded tissue. RESULTS: The mean proportion of PCNA positive cells was 18.6%, and there was no significant difference according to cell type and stage. The median survival time was significantly shorter in the group with high PCNA expression (>10%) as compared with the group with low PCNA expression (<10%) (37 months vs 16 months). Four (6.3%) of 64 cases demonstrated c-erbB-2 positivity. These were all adenocarcinoma cases. c-fos protein was only rarely overexpressed (1/51). CONCLUSION: PCNA expression was shown to be a useful prognostic parameter in resected non-small cell lung cancer while c-erbB-2 and c-fos oncoprotein were infrequently expressed.
Files in This Item:
T199902847.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Kim, Joo Hang(김주항)
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173951
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links