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비소세포성 폐암 환자에서 Proliferating Cell Nuclear Antigen, c-erb B-2 및 c-fos 단백질 발현과 예후와의 상관관계

DC Field Value Language
dc.contributor.author김세규-
dc.contributor.author김주항-
dc.contributor.author장준-
dc.date.accessioned2020-01-23T05:02:42Z-
dc.date.available2020-01-23T05:02:42Z-
dc.date.issued1999-
dc.identifier.issn0496-6872-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173951-
dc.description.abstractPURPOSE: Oncogenes, tumor suppressor genes, and growth variables of tumors are important in the assessment of prognosis in lung cancer. The expression of PCNA, c-erbB-2 (HER-2/neu), and c-fos oncoprotein and their prognostic implications in surgically resected patients with non-small cell lung cancer were evaluated. MATERIALS AND METHODS: Seventy patients with non-small cell lung cancer were included and PCNA, c-erbB-2 and c-fos overexpression were evaluated by immunohistochemical stain using paraffin-embedded tissue. RESULTS: The mean proportion of PCNA positive cells was 18.6%, and there was no significant difference according to cell type and stage. The median survival time was significantly shorter in the group with high PCNA expression (>10%) as compared with the group with low PCNA expression (<10%) (37 months vs 16 months). Four (6.3%) of 64 cases demonstrated c-erbB-2 positivity. These were all adenocarcinoma cases. c-fos protein was only rarely overexpressed (1/51). CONCLUSION: PCNA expression was shown to be a useful prognostic parameter in resected non-small cell lung cancer while c-erbB-2 and c-fos oncoprotein were infrequently expressed.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한암학회-
dc.relation.isPartOfJournal of the Korean Cancer Association (대한암학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title비소세포성 폐암 환자에서 Proliferating Cell Nuclear Antigen, c-erb B-2 및 c-fos 단백질 발현과 예후와의 상관관계-
dc.title.alternativePrognostic Value of PCNA , c-erbB-2 , c-fos in Patients with Non-small Cell Lung Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor이이형-
dc.contributor.googleauthor안중배-
dc.contributor.googleauthor신동환-
dc.contributor.googleauthor홍순원-
dc.contributor.googleauthor심정연-
dc.contributor.googleauthor정경영-
dc.contributor.googleauthor김세규-
dc.contributor.googleauthor장준-
dc.contributor.googleauthor김주항-
dc.contributor.googleauthor이원영-
dc.contributor.googleauthor김병수-
dc.contributor.googleauthor김성규-
dc.contributor.localIdA00602-
dc.contributor.localIdA00945-
dc.contributor.localIdA03472-
dc.relation.journalcodeJ01813-
dc.subject.keywordLung cancer-
dc.subject.keywordPCNA-
dc.subject.keywordc-erbB-2-
dc.subject.keywordc-fos-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.affiliatedAuthor김세규-
dc.contributor.affiliatedAuthor김주항-
dc.contributor.affiliatedAuthor장준-
dc.citation.volume31-
dc.citation.number4-
dc.citation.startPage678-
dc.citation.endPage685-
dc.identifier.bibliographicCitationJournal of the Korean Cancer Association (대한암학회지), Vol.31(4) : 678-685, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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