Cited 0 times in
비소세포성 폐암 환자에서 Proliferating Cell Nuclear Antigen, c-erb B-2 및 c-fos 단백질 발현과 예후와의 상관관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세규 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 장준 | - |
dc.date.accessioned | 2020-01-23T05:02:42Z | - |
dc.date.available | 2020-01-23T05:02:42Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173951 | - |
dc.description.abstract | PURPOSE: Oncogenes, tumor suppressor genes, and growth variables of tumors are important in the assessment of prognosis in lung cancer. The expression of PCNA, c-erbB-2 (HER-2/neu), and c-fos oncoprotein and their prognostic implications in surgically resected patients with non-small cell lung cancer were evaluated. MATERIALS AND METHODS: Seventy patients with non-small cell lung cancer were included and PCNA, c-erbB-2 and c-fos overexpression were evaluated by immunohistochemical stain using paraffin-embedded tissue. RESULTS: The mean proportion of PCNA positive cells was 18.6%, and there was no significant difference according to cell type and stage. The median survival time was significantly shorter in the group with high PCNA expression (>10%) as compared with the group with low PCNA expression (<10%) (37 months vs 16 months). Four (6.3%) of 64 cases demonstrated c-erbB-2 positivity. These were all adenocarcinoma cases. c-fos protein was only rarely overexpressed (1/51). CONCLUSION: PCNA expression was shown to be a useful prognostic parameter in resected non-small cell lung cancer while c-erbB-2 and c-fos oncoprotein were infrequently expressed. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 비소세포성 폐암 환자에서 Proliferating Cell Nuclear Antigen, c-erb B-2 및 c-fos 단백질 발현과 예후와의 상관관계 | - |
dc.title.alternative | Prognostic Value of PCNA , c-erbB-2 , c-fos in Patients with Non-small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 이이형 | - |
dc.contributor.googleauthor | 안중배 | - |
dc.contributor.googleauthor | 신동환 | - |
dc.contributor.googleauthor | 홍순원 | - |
dc.contributor.googleauthor | 심정연 | - |
dc.contributor.googleauthor | 정경영 | - |
dc.contributor.googleauthor | 김세규 | - |
dc.contributor.googleauthor | 장준 | - |
dc.contributor.googleauthor | 김주항 | - |
dc.contributor.googleauthor | 이원영 | - |
dc.contributor.googleauthor | 김병수 | - |
dc.contributor.googleauthor | 김성규 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A03472 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | Lung cancer | - |
dc.subject.keyword | PCNA | - |
dc.subject.keyword | c-erbB-2 | - |
dc.subject.keyword | c-fos | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | 김세규 | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 장준 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 678 | - |
dc.citation.endPage | 685 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.31(4) : 678-685, 1999 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.