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Effects of 0.005% latanoprost on optic nerve head and peripapillary retinal blood flow

Authors
 Gong Je Seong  ;  Hyung Keun Lee  ;  Young Jae Hong 
Citation
 Ophthalmologica, Vol.213(6) : 355-359, 1999 
Journal Title
 Ophthalmologica 
ISSN
 0030-3755 
Issue Date
1999
MeSH
Adult ; Blood Flow Velocity/drug effects ; Double-Blind Method ; Female ; Humans ; Intraocular Pressure/drug effects ; Laser-Doppler Flowmetry ; Latanoprost ; Male ; Ophthalmic Solutions/pharmacology ; Optic Disk/blood supply* ; Optic Disk/drug effects* ; Prostaglandins F, Synthetic/pharmacology* ; Reference Values ; Regional Blood Flow/drug effects ; Reproducibility of Results ; Retinal Vessels/drug effects* ; Retinal Vessels/physiology
Abstract
Fifty-two eyes of 26 healthy volunteers were recruited for evaluating the effects of 0.005% latanoprost on optic nerve head (ONH) and peripapillary retinal blood flow. In a randomized double-blind design, one eye received one drop of 0.005% latanoprost and its fellow eye received one drop of a placebo eyedrop. Intraocular pressure (IOP), ONH and peripapillary retinal blood flow were measured with Heidelberg retinal flowmetry (HRF) before, 2 and 24 h after administration of eyedrops. IOP was decreased significantly in latanoprost-treated eyes at 2 and 24 h after administration (p < 0.05). In the volume, flow or velocity of ONH and peripapillary retina, there were no significant changes from the baseline values at 2 and 24 h after latanoprost administration in either latanoprost-treated eyes or their fellow eyes (p > 0.05). No significant differences were found in the measured quantities between latanoprost-treated eyes and their fellow eyes at each time point (p > 0.05). This result may suggest that 0.005% latanoprost in healthy subjects does not have any adverse effect on ONH and peripapillary retinal blood flow.
Full Text
https://www.karger.com/Article/FullText/27454
DOI
10.1159/000027454
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173855
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