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Effects of mannitol and dimethylthiourea on helicobacter pylori-induced IL-8 production in gastric epithelial cells

Authors
 Hyeyoung Kim  ;  Jeong Yeon Seo  ;  Kyung Hwan Kim 
Citation
 Pharmacology, Vol.59(4) : 201-211, 1999 
Journal Title
 Pharmacology 
ISSN
 0031-7012 
Issue Date
1999
MeSH
Cell Line ; Cytokines/biosynthesis ; Diuretics, Osmotic/pharmacology* ; Electrophoresis ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism* ; Free Radical Scavengers/pharmacology* ; Gastric Mucosa/metabolism* ; Gastric Mucosa/pathology ; Helicobacter Infections/metabolism* ; Helicobacter pylori* ; Humans ; Hydroxyl Radical/metabolism ; Interleukin-8/biosynthesis* ; Lipid Peroxidation/drug effects ; Mannitol/pharmacology* ; NF-kappa B/metabolism ; Thiourea/analogs & derivatives* ; Thiourea/pharmacology
Abstract
The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, treated with or without mannitol and dimethylthiourea, was incubated in the absence or the presence of H. pylori. As a result, H. pylori significantly stimulated the productions of lipid peroxide and IL-8. Treatment with H. pylori resulted in the activation of two species of NF-kappa B dimers (a p50/p65 heterodimer and a p50 homodimer). Mannitol and dimethylthiourea significantly inhibited lipid peroxide production, NF-kappa B complex formation and IL-8 production by H. pylori. In conclusion, mannitol and dimethylthiourea may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and NF-kappa B activation and thereby decreasing IL-8 production.
Full Text
https://www.karger.com/Article/Abstract/28321
DOI
10.1159/000028321
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173844
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