Cited 37 times in
Effects of mannitol and dimethylthiourea on helicobacter pylori-induced IL-8 production in gastric epithelial cells
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2020-01-10T02:04:06Z | - |
dc.date.available | 2020-01-10T02:04:06Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173844 | - |
dc.description.abstract | The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, treated with or without mannitol and dimethylthiourea, was incubated in the absence or the presence of H. pylori. As a result, H. pylori significantly stimulated the productions of lipid peroxide and IL-8. Treatment with H. pylori resulted in the activation of two species of NF-kappa B dimers (a p50/p65 heterodimer and a p50 homodimer). Mannitol and dimethylthiourea significantly inhibited lipid peroxide production, NF-kappa B complex formation and IL-8 production by H. pylori. In conclusion, mannitol and dimethylthiourea may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and NF-kappa B activation and thereby decreasing IL-8 production. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | Pharmacology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Diuretics, Osmotic/pharmacology* | - |
dc.subject.MESH | Electrophoresis | - |
dc.subject.MESH | Epithelial Cells/drug effects | - |
dc.subject.MESH | Epithelial Cells/metabolism* | - |
dc.subject.MESH | Free Radical Scavengers/pharmacology* | - |
dc.subject.MESH | Gastric Mucosa/metabolism* | - |
dc.subject.MESH | Gastric Mucosa/pathology | - |
dc.subject.MESH | Helicobacter Infections/metabolism* | - |
dc.subject.MESH | Helicobacter pylori* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxyl Radical/metabolism | - |
dc.subject.MESH | Interleukin-8/biosynthesis* | - |
dc.subject.MESH | Lipid Peroxidation/drug effects | - |
dc.subject.MESH | Mannitol/pharmacology* | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Thiourea/analogs & derivatives* | - |
dc.subject.MESH | Thiourea/pharmacology | - |
dc.title | Effects of mannitol and dimethylthiourea on helicobacter pylori-induced IL-8 production in gastric epithelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.contributor.googleauthor | Jeong Yeon Seo | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.identifier.doi | 10.1159/000028321 | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J02509 | - |
dc.identifier.eissn | 1423-0313 | - |
dc.identifier.pmid | 10474080 | - |
dc.identifier.url | https://www.karger.com/Article/Abstract/28321 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 59 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 201 | - |
dc.citation.endPage | 211 | - |
dc.identifier.bibliographicCitation | Pharmacology, Vol.59(4) : 201-211, 1999 | - |
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