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Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis

 Won-Yoon Chung  ;  Jong-Min Lee  ;  Mi-Young Park  ;  Jong-In Yook  ;  Jin Kim  ;  An-Sik Chung  ;  Young-Joon Surh  ;  Kwang-Kyun Park 
 Cancer Letters, Vol.145(1~2) : 57-64, 1999 
Journal Title
 Cancer Letters 
Issue Date
9,10-Dimethyl-1,2-benzanthracene/antagonists & inhibitors* ; Animals ; Anticarcinogenic Agents/therapeutic use* ; Antimutagenic Agents/therapeutic use* ; Chemoprevention ; Chlorophyllides/therapeutic use* ; Female ; Male ; Mice ; Mice, Inbred ICR ; Rats ; Rats, Sprague-Dawley ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/genetics ; Skin Neoplasms/prevention & control* ; Tetradecanoylphorbol Acetate/toxicity
Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutagenesis in Salmonella typhimurium TA100 and also on DMBA-initiated and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-promoted mouse skin tumor formation. The incidence and the multiplicity of skin tumors were not significantly decreased in mice by a single topical application of CHL prior to the DMBA treatment, but there was a marked suppression of papillomagenesis in mice treated with CHL during the promotional stage. Furthermore, the formation of DMBA-induced papillomagenesis was reduced in all mice that had received CHL for 6 weeks following treatment with TPA for 6, 18 and 24 weeks. These results indicate that CHL can inhibit both tumor promotion and the progression of papillomagenesis in the two-stage mouse skin carcinogenesis induced by DMBA and TPA.
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2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Park, Kwang Kyun(박광균)
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
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