Cited 21 times in
Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis
DC Field | Value | Language |
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dc.contributor.author | 김진 | - |
dc.contributor.author | 박광균 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2020-01-10T02:03:46Z | - |
dc.date.available | 2020-01-10T02:03:46Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173842 | - |
dc.description.abstract | Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mutagenesis in Salmonella typhimurium TA100 and also on DMBA-initiated and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-promoted mouse skin tumor formation. The incidence and the multiplicity of skin tumors were not significantly decreased in mice by a single topical application of CHL prior to the DMBA treatment, but there was a marked suppression of papillomagenesis in mice treated with CHL during the promotional stage. Furthermore, the formation of DMBA-induced papillomagenesis was reduced in all mice that had received CHL for 6 weeks following treatment with TPA for 6, 18 and 24 weeks. These results indicate that CHL can inhibit both tumor promotion and the progression of papillomagenesis in the two-stage mouse skin carcinogenesis induced by DMBA and TPA. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Ireland | - |
dc.relation.isPartOf | Cancer Letters | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | 9,10-Dimethyl-1,2-benzanthracene/antagonists & inhibitors* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anticarcinogenic Agents/therapeutic use* | - |
dc.subject.MESH | Antimutagenic Agents/therapeutic use* | - |
dc.subject.MESH | Chemoprevention | - |
dc.subject.MESH | Chlorophyllides/therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Salmonella typhimurium/drug effects | - |
dc.subject.MESH | Salmonella typhimurium/genetics | - |
dc.subject.MESH | Skin Neoplasms/prevention & control* | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/toxicity | - |
dc.title | Inhibitory effects of chlorophyllin on 7,12-dimethylbenz[a]anthracene-induced bacterial mutagenesis and mouse skin carcinogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학교실) | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Mi-Young Park | - |
dc.contributor.googleauthor | Jong-In Yook | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | An-Sik Chung | - |
dc.contributor.googleauthor | Young-Joon Surh | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.identifier.doi | 10.1016/s0304-3835(99)00229-3 | - |
dc.contributor.localId | A01009 | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03676 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 10530770 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304383599002293 | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.affiliatedAuthor | 김진 | - |
dc.contributor.affiliatedAuthor | 박광균 | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.contributor.affiliatedAuthor | 정원윤 | - |
dc.citation.volume | 145 | - |
dc.citation.number | 1~2 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 64 | - |
dc.identifier.bibliographicCitation | Cancer Letters, Vol.145(1~2) : 57-64, 1999 | - |
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