DMBA로 유발한 햄스터 협낭암에 대한 클로로필린의 억제효과

Abstract

Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL is antimutagenic and anticarcinogenic against various carcinogens in vitro and in vivo. In the present study, CHL exhibited dose-related inhibition of His+ reversion in Salmonella typhimurium TA98 induced by 7,12-dimethylbenz[a]anthracene (DMBA). Formation of DNA adducts from DMBA was also attenuated in the presence of CHL. Topical application of CHL prior to the topical application of DMBA resulted in significant reduction in both incidence and multiplicity of tumors in hamster buccal pouch. These results suggest that CHL may act as a potential chemopreventive agent against oral cancer.