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DMBA로 유발한 햄스터 협낭암에 대한 클로로필린의 억제효과

Other Titles
 The Inhibition of DMBA-Induced Carcinogenesis by CHL in Hamster Buccal Pouch 
Authors
 이종민  ;  정원윤  ;  박광균 
Citation
 대한암예방학회지(jkoreanassociationofcancerprevention), Vol.4(3) : 127-135, 1999 
Journal Title
 대한암예방학회지(jkoreanassociationofcancerprevention) 
ISSN
 1229-0165 
Issue Date
1999
Keywords
Chlorophyllin ; DNA adduct ; Antimutagenic activity ; Anticarcinogenic activity
Abstract
Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL is antimutagenic and anticarcinogenic against various carcinogens in vitro and in vivo. In the present study, CHL exhibited dose-related inhibition of His+ reversion in Salmonella typhimurium TA98 induced by 7,12-dimethylbenz[a]anthracene (DMBA). Formation of DNA adducts from DMBA was also attenuated in the presence of CHL. Topical application of CHL prior to the topical application of DMBA resulted in significant reduction in both incidence and multiplicity of tumors in hamster buccal pouch. These results suggest that CHL may act as a potential chemopreventive agent against oral cancer.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173814
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