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DMBA로 유발한 햄스터 협낭암에 대한 클로로필린의 억제효과

DC FieldValueLanguage
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.date.accessioned2020-01-07T08:46:02Z-
dc.date.available2020-01-07T08:46:02Z-
dc.date.issued1999-
dc.identifier.issn1229-0165-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173814-
dc.description.abstractChlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL is antimutagenic and anticarcinogenic against various carcinogens in vitro and in vivo. In the present study, CHL exhibited dose-related inhibition of His+ reversion in Salmonella typhimurium TA98 induced by 7,12-dimethylbenz[a]anthracene (DMBA). Formation of DNA adducts from DMBA was also attenuated in the presence of CHL. Topical application of CHL prior to the topical application of DMBA resulted in significant reduction in both incidence and multiplicity of tumors in hamster buccal pouch. These results suggest that CHL may act as a potential chemopreventive agent against oral cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean, English-
dc.publisher대한암예방학회-
dc.relation.isPartOf대한암예방학회지(jkoreanassociationofcancerprevention)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDMBA로 유발한 햄스터 협낭암에 대한 클로로필린의 억제효과-
dc.title.alternativeThe Inhibition of DMBA-Induced Carcinogenesis by CHL in Hamster Buccal Pouch-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthor이종민-
dc.contributor.googleauthor정원윤-
dc.contributor.googleauthor박광균-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ01500-
dc.subject.keywordChlorophyllin-
dc.subject.keywordDNA adduct-
dc.subject.keywordAntimutagenic activity-
dc.subject.keywordAnticarcinogenic activity-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor정원윤-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage127-
dc.citation.endPage135-
dc.identifier.bibliographicCitation대한암예방학회지(jkoreanassociationofcancerprevention), Vol.4(3) : 127-135, 1999-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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