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Anti-T antibodies and peanut-agglutinin-binding glycoproteins in sera of patients with gastric cancer

Authors
 Il-Ran Hwang  ;  Dong-Ho Nahm  ;  Sang-Nae Cho  ;  B. Michael Longenecker  ;  R. Rao Koganty & In Suh Park 
Citation
 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.125(10) : 582-587, 1999 
Journal Title
 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 
ISSN
 0171-5216 
Issue Date
1999
MeSH
Adult ; Aged ; Agglutinins/metabolism ; Antibodies, Neoplasm/blood* ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Glycoproteins/blood* ; Humans ; Male ; Middle Aged ; Peanut Agglutinin/metabolism* ; Plant Lectins ; Protein Binding ; Stomach Neoplasms/blood* ; Stomach Neoplasms/immunology ; T-Lymphocytes/immunology* ; Triticum
Abstract
Agglutinating antibodies to neuraminidase-treated red blood cells (anti-T agglutinins) are known to be reduced in patients with gastric cancer. The antigenic determinant of anti-T agglutinin is known to have a disaccharide structure [Gal(beta1-3)GalNAc], the same specificity as peanut agglutinin (PNA). We examined sera of 27 patients with gastric cancer and 30 controls for anti-T agglutinins, anti-T antibodies and PNA-binding glycoproteins. Anti-T agglutinins were titrated by a microtiter hemagglutination method. Levels of anti-T antibodies were determined by enzyme immunoassay using synthetic glycoconjugate [Gal(beta1-3)GalNAc O-alpha-linked to human serum albumin] as an antigen. Levels of PNA-binding glycoproteins in sera were measured by sandwich enzyme-linked lectin assay using wheat germ agglutinin and peroxidase-conjugated PNA. Titers of anti-T agglutinins were significantly lower in patients with gastric cancer than in controls (P = 0.041). Levels of anti-T antibodies were not significantly different in patients with gastric cancer and controls; however, decreased levels of anti-T antibodies were more frequent in patients with gastric cancer than in controls (P = 0. 001). Levels of PNA-binding glycoproteins were significantly higher in sera of patients with gastric cancer than in controls (P = 0.001). The levels of anti-T antibodies inversely correlated with the levels of PNA-binding glycoproteins in sera of patients with gastric cancer (r = -0.44, P = 0.021). These results suggest that the decrease in anti-T antibodies in sera of patients with gastric cancer might be due to immune complex formation between circulating PNA-binding glycoproteins and anti-T antibodies.
Full Text
https://link.springer.com/article/10.1007%2Fs004320050320
DOI
10.1007/s004320050320
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173782
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