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Anti-T antibodies and peanut-agglutinin-binding glycoproteins in sera of patients with gastric cancer

DC FieldValueLanguage
dc.contributor.author조상래-
dc.date.accessioned2020-01-07T08:42:48Z-
dc.date.available2020-01-07T08:42:48Z-
dc.date.issued1999-
dc.identifier.issn0171-5216-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173782-
dc.description.abstractAgglutinating antibodies to neuraminidase-treated red blood cells (anti-T agglutinins) are known to be reduced in patients with gastric cancer. The antigenic determinant of anti-T agglutinin is known to have a disaccharide structure [Gal(beta1-3)GalNAc], the same specificity as peanut agglutinin (PNA). We examined sera of 27 patients with gastric cancer and 30 controls for anti-T agglutinins, anti-T antibodies and PNA-binding glycoproteins. Anti-T agglutinins were titrated by a microtiter hemagglutination method. Levels of anti-T antibodies were determined by enzyme immunoassay using synthetic glycoconjugate [Gal(beta1-3)GalNAc O-alpha-linked to human serum albumin] as an antigen. Levels of PNA-binding glycoproteins in sera were measured by sandwich enzyme-linked lectin assay using wheat germ agglutinin and peroxidase-conjugated PNA. Titers of anti-T agglutinins were significantly lower in patients with gastric cancer than in controls (P = 0.041). Levels of anti-T antibodies were not significantly different in patients with gastric cancer and controls; however, decreased levels of anti-T antibodies were more frequent in patients with gastric cancer than in controls (P = 0. 001). Levels of PNA-binding glycoproteins were significantly higher in sera of patients with gastric cancer than in controls (P = 0.001). The levels of anti-T antibodies inversely correlated with the levels of PNA-binding glycoproteins in sera of patients with gastric cancer (r = -0.44, P = 0.021). These results suggest that the decrease in anti-T antibodies in sera of patients with gastric cancer might be due to immune complex formation between circulating PNA-binding glycoproteins and anti-T antibodies.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, German-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAgglutinins/metabolism-
dc.subject.MESHAntibodies, Neoplasm/blood*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHGlycoproteins/blood*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeanut Agglutinin/metabolism*-
dc.subject.MESHPlant Lectins-
dc.subject.MESHProtein Binding-
dc.subject.MESHStomach Neoplasms/blood*-
dc.subject.MESHStomach Neoplasms/immunology-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.subject.MESHTriticum-
dc.titleAnti-T antibodies and peanut-agglutinin-binding glycoproteins in sera of patients with gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorIl-Ran Hwang-
dc.contributor.googleauthorDong-Ho Nahm-
dc.contributor.googleauthorSang-Nae Cho-
dc.contributor.googleauthorB. Michael Longenecker-
dc.contributor.googleauthorR. Rao Koganty & In Suh Park-
dc.identifier.doi10.1007/s004320050320-
dc.contributor.localIdA03824-
dc.relation.journalcodeJ01283-
dc.identifier.eissn1432-1335-
dc.identifier.pmid10473872-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs004320050320-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.affiliatedAuthor조상래-
dc.citation.volume125-
dc.citation.number10-
dc.citation.startPage582-
dc.citation.endPage587-
dc.identifier.bibliographicCitationJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.125(10) : 582-587, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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