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DEB(Drug-eluting beads)-TACE for the treatment of small hepatocellular carcinoma

Other Titles
 소간세포암의 치료에서의 약물 방출성 bead를 이용한 경동맥 항암화학 색전술 
Authors
 이여진 
College
 Graduate School, Yonsei University 
Department
 Dept. of Medicine 
Degree
석사
Issue Date
2013
Abstract
Purpose: To assess the efficacy of transarterial chemoembolization using drug-eluting beads (DEB-TACE) in patients with small HCC (≤ 2 cm). Materials and Methods: This study enrolled 36 patients with small HCC underwent DEB-TACE since September 2009. Liver function status of all patients was either Child-Pugh class A (n=33) or B (n=3). The size of DEB was either 100-300 (n=20) or 300-500 (n=16) µm and the maximum loading dose of chemotherapeutic agent was 70 mg of doxorubicin in one vial of beads. Tumor response rate was assessed according to EASL criteria.Results: There were no major complications except mild transient post-embolization syndrome. All but one maintained initial Child-Pugh score. Until last follow-up period (1-24 months), EASL criteria rated 86%, 80.5%, 77.7% of CR, 8.3%, 8.3%, 16.6% of PR, 5.5%, 5.5%, 5.5% and 0%, 5.5%, 5.5% of PD (94.4%, 88.8%, 94.3% of OR) at 1 month, 3-6 months, and 12 months respectively. CR rate was higher in patients treated by smaller size of beads (100-300 µm). Conclusion: DEB-TACE was considered as a safe modality for the treatment of small HCC, and showed good tumor response rate in this mid-term result.
Appears in Collections:
7. Others (기타) > Others (기타) > 5. Others
Yonsei Authors
Lee, Yeo Jin(이여진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173583
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