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Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults

 Sang Bae Lee  ;  Min Kyung Kim  ;  Shinae Kang  ;  Kahui Park  ;  Jung Hye Kim  ;  Su Jung Baik  ;  Ji Sun Nam  ;  Chul Woo Ahn  ;  Jong Suk Park 
 Endocrinology and Metabolism (대한내분비학회지), Vol.34(2) : 179-186, 2019 
Journal Title
Endocrinology and Metabolism(대한내분비학회지)
Issue Date
Insulin resistance ; Non-alcoholic fatty liver disease ; Triglyceride glucose index
BACKGROUND: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance which is a well-known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and NAFLD. Thus, we investigated the relationship between the TyG index and NAFLD and the effectiveness of the TyG index compared with the homeostasis model assessment of insulin resistance (HOMA-IR) in identifying NAFLD in Korean adults.

METHODS: Participants of 4,986 who underwent ultrasonography in a health promotion center were enrolled. The TyG index was calculated as ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2], and HOMA-IR was estimated. NAFLD was diagnosed by ultrasonography.

RESULTS: Significant differences were observed in metabolic parameters among the quartiles of the TyG index. The prevalence of NAFLD significantly increased with increment in the TyG index. After adjusting for multiple risk factors, a logistic regression analysis was performed. When the highest and lowest quartiles of the TyG index and HOMA-IR were compared, the odds ratios for the prevalence of NAFLD were 2.94 and 1.93 (95% confidence interval, 2.32 to 3.72 and 1.43 to 2.61; both P for trend <0.01), respectively. According to the receiver operating characteristic analysis, the TyG index was superior to HOMA-IR in predicting NAFLD.

CONCLUSION: The TyG index and prevalence of NAFLD were significantly related and the TyG index was superior to HOMA-IR in predicting NAFLD in Korean adults.
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Appears in Collections:
6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Jung Hye(김정혜)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Kahui(박가희)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
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