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Impact of metabolic syndrome-related factors on the development of benign prostatic hyperplasia and lower urinary tract symptoms in Asian population

Authors
 Jee Soo Park  ;  Kyo Chul Koo  ;  Hye Kyung Kim  ;  Byung Ha Chung  ;  Kwang Suk Lee 
Citation
 MEDICINE, Vol.98(42) : e17635, 2019 
Journal Title
 MEDICINE 
ISSN
 0025-7974 
Issue Date
2019
MeSH
Aged ; Biomarkers/blood ; Biopsy ; Blood Glucose/metabolism ; Body Mass Index ; Cholesterol, LDL/blood* ; Disease Progression ; Endosonography ; Follow-Up Studies ; Humans ; Incidence ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/epidemiology ; Lower Urinary Tract Symptoms/etiology* ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/complications* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Prognosis ; Prostate/diagnostic imaging ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/etiology* ; Rectum ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment/methods* ; Risk Factors
Abstract
This study aimed to investigate the metabolic syndrome-related risk factors for the development of benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS) in healthy men.A total of 4880 healthy men who underwent transrectal ultrasonography at our hospital during routine health examinations were included in this study. Those who had undergone a prior biopsy or surgery for prostate disease, were suspected of having urinary tract infection, or were taking BPH/LUTS or metabolic syndrome medications were excluded. BPH/LUTS was defined as an International Prostate Symptom Score (IPSS) of ≥8 and a prostate volume (PV) of ≥30 cm.The subjects had a mean age of 54.1 years, PV of 29.2 cm, prostate-specific antigen (PSA) level of 1.20 ng/mL, and IPSS of 9.2. The annual PV growth rate was 0.48 cm/year. Age, body mass index (BMI), PSA, basal metabolic rate, apolipoprotein A-1, fasting blood glucose, high-density lipoprotein (HDL) cholesterol levels were significant predictive factors for PV. Age, PSA, apolipoprotein B, fasting blood glucose, cholesterol, HDL, and low-density lipoprotein (LDL) levels were predictors of BPH/LUTS at the initial health examination. A decreased fat mass and LDL level were a significant risk factor for the development of BPH/LUTS within 5 years in men without a BPH/LUTS diagnosis at the initial examination.Metabolic syndrome-related variables were strongly associated with BPH/LUTS and by decreasing fat mass and LDL levels, development of BPH/LUTS could be prevented within 5 years in healthy Korean men.
Files in This Item:
T201904193.pdf Download
DOI
10.1097/MD.0000000000017635
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Koo, Kyo Chul(구교철) ORCID logo https://orcid.org/0000-0001-7303-6256
Kim, Hye Kyung(김혜경)
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Lee, Kwang Suk(이광석) ORCID logo https://orcid.org/0000-0002-7961-8393
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173163
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